@seanstidston Nattokinase in combination with Serrapeptase (but use high quality versions, some brands do nothing at all).
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Mich E
5.6K posts
Mich E
@mr_mich_e
Christen † - 2 Kor 5:14-15 - Al het goede in mij door God's genade. En opweg naar meer... Normaal mens met talent in ICT (programmeur .NET, PHP, etc.)
Katılım Mart 2010
2K Takip Edilen327 Takipçiler
What do people truly think can target the clotting pathology and endothelial issues upstream. Ivig ? Antivirals ? Triple therapy didn’t make me any better functionally but having stopped it, it’s clear that it was doing something and clotting is clearly a thing.
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@waldron509 @NeuroSjogrens @blinkyblueeyed @amatica If you want to look at AI analyzing your amatica results, I have a post for this: x.com/mr_mich_e/stat…
Mich E@mr_mich_e
With the results coming in from Amatica Health @amaticahealth and people wanting to analyze their results using AI. This is how I approach it: #LongCovid Keep in mind, this is NO medical advice, but might be helpful in getting more clarity on a way forward.
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@NeuroSjogrens @blinkyblueeyed @amatica Can I ask what AI tool you used please? I’m a bit overwhelmed by the volume of results and how to interpret, delighted to have evidence that is now consistent with symptoms and some blood tests now from Amatica rna sequencing, this is surely the way forward with health!
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Early results from my stack targeted by my @Amatica 20K RNA results: 1) improved sleep even tho stopped ambien/cannabis 2) nap sleep drive returning tiny bit 3) sense of hunger 4) bowel function better 5) Impr stress tolerance. Optimistic re ⬆️ parasympathetic "rest/digest."...
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@drtaubraun Probably different then Nattokinase, Serrapeptase or Lumbrokinase?
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Do you think I'd be popular around here if I just found something that could help prevent and reduce the amyloid fibrins (fibrinaloids)? More soon! Super excited.
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@DuaneStorey Also according to the AI: This is potential evidence of ORF8 epigenetic scar on specific promoters (CDKN1A, SESN2, possibly NOB1/LAS1L). If ORF8 is physically present in the nucleolus, it could directly interfere with the NOB1/LAS1L pre-rRNA processing.
Could this be tested?
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1. Active free-ribosomal-protein sensing: the cell can't finish assembling ribosomes. This is the most lab-prep-robust signal in your data: same magnitude across two different labs, 6 months apart. RPL5 and RPL11 are identical both samples (+3.87 vs +3.91, essentially the same z-score). These are the ribosomal proteins that bind MDM2 when they can't be incorporated into 60S subunits. Their elevation means free RPs are accumulating.
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I finished analyzing the weirdness in my QC traces using my new pipeline stage, and AI of course to help me interpret it all. I won't spend a ton of time doing this analysis myself until the end, but here's what appears to be happening with my ribosomes (AI below):
The overall picture is: chronic nucleolar stress with selective internal 3' pre-rRNA processing failure and broken p53 surveillance
Duane Storey@DuaneStorey
Added a new RNA pipeline stage last night to investigate the weird ribosomal biogenesis data my day 0 sample showed. Running it against myself and all the controls now. I should be able to see the exact points where it's breaking down I hope.
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@DuaneStorey My AI on this information found a possible new explanation on PEM with this information:
PEM being caused by translational debt during exertion
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@jerrynixon I made, for these use cases a SQL Server ReadOnly MCP server. Which has certain mechanisms for controlled access and even readonly or schema only. See: github.com/meghuizen/SqlR…
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Introducing SQL MCP Server devblogs.microsoft.com/azure-sql/intr…
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Mich E retweetledi
OpenAI just open sourced a new 1.5B (50m active) model on HuggingFace with Apache 2.0 license!
It's not a new LLM, this one is called Privacy Filter, and it's a PII detection model (checking if text has private information)
A few interesting tidbits from the release + links:
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Mich E retweetledi
Mich E retweetledi
Instead of watching Netflix tonight, watch this 2-hour Stanford lecture.
You’ll learn more about how ChatGPT, Claude, and other LLMs are built than most people at top AI companies learn in years.
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@HilpeaSika @DuaneStorey I don't use only prompts, I also use tools like graph databases to map the information and also thinking mcp tools like clear-though (currently building my own).
For the rest this is my approach: x.com/mr_mich_e/stat…
Mich E@mr_mich_e
With the results coming in from Amatica Health @amaticahealth and people wanting to analyze their results using AI. This is how I approach it: #LongCovid Keep in mind, this is NO medical advice, but might be helpful in getting more clarity on a way forward.
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@mr_mich_e @DuaneStorey Could you share the prompts you used?
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Rapamycin made me worse as well. When I got my first RNA seq data, I could see why it was a bit risky.
"The mTORC1 pathway is already disrupted. Sirolimus could theoretically help via autophagy promotion and trained-immunity modulation, but because the target pathway is already abnormal, this is a high-uncertainty option."
Dr Brad Stanfield@BradStanfieldMD
Our Rapamycin & Exercise clinical trial has just been published! The topline result? Rapamycin didn't help. Instead, it may have made things worse. Here's what we found 🧵 onlinelibrary.wiley.com/doi/epdf/10.10…
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@DuaneStorey Yes, limited data doesn't give the full perspective. Where you able to find connections from your RNA data, blood samples other tests and map those out?
I think if cross domain mapping can be done we might be able to find connections which currently aren't know yet.
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I've done a ton of analysis on it already using various AI tools, including some I've written. With only a small piece of the data it's not going to be able to make any good recommendations. For example I'm on a GLP1 with already low blood sugar - both time restricted feeding and metformin aren't good ideas for me. Without seeing the whole picture it's just guessing. Appreciate the effort though.
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@DuaneStorey True, and I understand. But I was interested to see what information out of the data out of amatica you could get and how to give AI the usefull tools for that. I ofcource don't have a full sequencing pipeline like you, but I follow your research with fascination. :)
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@mr_mich_e Thanks.. You've only seen a subset of the data though, I have the entire set. But sirolimus made me feel worse. I suspect it does help some people, I'm just not one of them.
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@DuaneStorey Did remdesvir not cause a lot of kidney failure? Doesn't this have similar effect?
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🤨 People keep asking how to protect yourself.
#1: set min-release-age=7 in .npmrc
#2: install Socket for GitHub (it's free!) to protect PRs from bad dependencies: socket.dev/features/github
#3: install Socket Firewall (also free!) to protect your laptop: socket.dev/features/firew…
Feross@feross
🚨 CRITICAL: Active supply chain attack on axios -- one of npm's most depended-on packages. The latest axios@1.14.1 now pulls in plain-crypto-js@4.2.1, a package that did not exist before today. This is a live compromise. This is textbook supply chain installer malware. axios has 100M+ weekly downloads. Every npm install pulling the latest version is potentially compromised right now. Socket AI analysis confirms this is malware. plain-crypto-js is an obfuscated dropper/loader that: • Deobfuscates embedded payloads and operational strings at runtime • Dynamically loads fs, os, and execSync to evade static analysis • Executes decoded shell commands • Stages and copies payload files into OS temp and Windows ProgramData directories • Deletes and renames artifacts post-execution to destroy forensic evidence If you use axios, pin your version immediately and audit your lockfiles. Do not upgrade.
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Mich E retweetledi
Absolutely wild seeing a molecular simulation in real time using femtosecond scales.. I'm literally watching a drug settle into a covid19 pocket in real time. Technology is so cool.
This is a drug targeting the proofreading enzyme of SARS-CoV-2, nsp14 ExoN. The entire timescale will only be 20 nanoseconds to start, and even that is about four hours of hardcore GPU computation.
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@kirstymecfslife Could be hypothyroidism or parasympathetic dominance (this can even be when you also have sympathic dominance at the same time).
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@zagreusrevival I got the same spots. Any clue?
And for the things not working, the combi on nmn + coq10 + pqq + mitoq as a combined effort, would that work?
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🔎Gut dysbiosis: abdominal ultrasound
- periodic strong pain: mainly around gallbladder (always same spot) and different spots around rest of large intestine
- constipation
- bowel movement: 1-2x/w
- strong biofilm on tongue, likely candida, suggesting same in gut
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Starting my #LongCovid Recovery Journal.
Will keep adding my findings, mistakes, takeaways here until I recover or I am no more. Hopefully helpful.
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Mich E retweetledi
I treat CHF, long COVID, autism, anxiety, cancer patients—daily.
And this post made my stomach drop.
Not just because Bifidobacteria are vanishing…
…but because almost no one is asking why fields fail first.
🧠 Bifido don’t just digest—they signal. They sync clocks, shape immune tone, and modulate redox gradients.
🧲 They’re early field antennas—tuned to light, magnetism, and circadian cues.
No Bifido = no field translation.
No field = no coherent gut-brain development.
Your thread is a signal fire, Sabine.
I’m listening.
So are my patients.
— @DrGrimmMD | drgrimmmd.substack.com
🧬 (Easter egg: probiotics that don’t entrain circadian phase = noise. Bifido know what time it is.)
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