Michael T Wolfinger

Next week in Vienna, I'll be speaking at #RNALeaders Europe about RNA structure prediction with modified nucleotides and the role of the ViennaRNA Package in advancing computational RNA analysis. app.ingo.me/q/q2n3r #RNA #ViennaRNA #Vienna #RNAtherapeutics #RNAvaccines

Beyond #syntheticBiology this opens new avenues for RNA therapeutics: mechanically defined RNA elements that enhance transcript stability and protect RNAs from exonucleolytic decay without relying on native viral sequences #RNAbiology #RNAstructure #RNATherapeutics #ViennaRNA

To our knowledge, this is the first example of a fully de novo engineered non-coding RNA with experimentally validated mechanical function. Using topology- and mechanics-aware design, synthetic xrRNAs reproduce wild-type-like resistance to 5′→3′ exonucleases.

🧬 New preprint out! Rational design of mechanically active RNAs: de novo engineering of functional exoribonuclease-resistant RNAs (xrRNAs). We demonstrate that RNA mechanical function can be designed from first principles without relying on evolutionary sequence ancestry.

ViennaRNA Package v2.7.1 is out! 🧬🎉 Solid update: smoother probing-informed folding (SHAPE/DMS), improved constraints handling, and nicer Python multistrand base-pair probs. Get: tbi.univie.ac.at/RNA/ Source: github.com/ViennaRNA/Vien… #ViennaRNA #RNA #ComputationalBiology

Calling #RNA & #Virology researchers! 🧬🦠 Submissions are open for the open-access Special Issue '𝗙𝘂𝗻𝗰𝘁𝗶𝗼𝗻𝗮𝗹 𝗥𝗡𝗔𝘀 𝗶𝗻 𝗩𝗶𝗿𝗼𝗹𝗼𝗴𝘆' in MDPI Viruses, which I'm guest editing. 📝 Original research & reviews! 🗓️ Deadline: Feb 28, 2026 michaelwolfinger.com/blog/2025/blog…

Calling all #RNA & #AI researchers! 🧬🤖 Submissions are open for the new open‑access collection “Exploring RNA Biology with Deep Learning Algorithms” in RNA Biology that I am guest editing with @YiliangDing 📄⬇️ michaelwolfinger.com/blog/2025/blog… #DeepLearning #bioinformatics #CompBio

🚀 Our new review unveils how Musashi proteins engage UAG & AGAA motifs in viral RNAs, revealing hijack tactics & guiding next-gen antivirals! 🦠💊 Dive in 👉 michaelwolfinger.com/files/papers/D… #RNAProtein #AntiviralTherapy #ComputationalBiology #RNA #virus #Zika

Do you love RNA biology and RNA structure? Join us at Atomic AI to shape the future of AI-driven drug discovery targeting RNA! We’re hiring for a computational RNA expert - check out this job posting here: tinyurl.com/2fpn2xjh

Happy to be featured in this Technology Feature by Michael Eisenstein in Nature Methods about the present and future of #RNA structure analysis, along with @ywan_wan, @RouskinLab, @JosephYesselman and many other colleagues working in this amazing field! nature.com/articles/s4159…

Zwei schwere #Borna #Virus 🦠-Fälle in #Bayern Der @donaukurier berichtet sehr sachlich & ohne Panikmache! Das Bernhard-Nocht-Institut ist das Konsiliarlabor für Bornaviren und steht für alle Fragen zur Verfügung. ⁦@hh_bwfgb⁩ ⁦@unihh⁩ donaukurier.de/lokales/landkr…

Insect flaviviruses (replication deficient in human cells) as vector for arbovirus vaccines: example of recombinant virus developing protective immunity in macaques pmc.ncbi.nlm.nih.gov/articles/pmid/…

Please retweet 🙏: 2 @ERC_Research-funded Post-doc positions are available in our lab to investigate #RNA structural ensemble and their dynamics in living cells. Application link: rug.nl/about-ug/work-…

#ViennaRNA v2.7.0 is out 🎉 with G-quadruplex support for circular RNAs, new methods for integrating #RNA structure probing data & energy parameters for modified bases like m5C and N1-methyl-pseudouridine. Plus many API improvements and bug fixes tbi.univie.ac.at/RNA/ #Vienna

Thrilled to have our outstanding PhD students, Leonhard Sidl and Jule Walter present our latest findings on artificial xrRNAs and synthetic xrRNA riboswitches at the German Conference on Synthetic Biology. #GCSB #computationalbiology #biochemistry #RNA #ViennaRNA

Very excited to share our latest preprint, led by rockstar post-doc @i_borovska. Our humble attempt to begin exploring #RNA secondary structure ensembles in a living cell (biorxiv.org/content/10.110…) (1/n)

West Nil Virus in Österreich - 21 Fälle bestätigt (Stand 3.9.2024) - davon 10 neurologische Erkrankungen - NÖ, Bgld, Wien, sowie importierte Fälle aus Kroatien und Ungarn #NationalesReferenzzentrum für humane #Arbovirusinfektionen #MedUniWien KARTE ages.at/mensch/krankhe…

@YannPonty @ppgardne Both of you will be missed!!!

On the way to #Barcelona to attend the 2024 #Benasque #RNA meeting for the next two weeks 🧬🌐

Excited to share our latest paper /w @RhysHParry on Xinyang flavivirus (XiFV) discovery in ticks from #China! Our research unveils unique structural #RNAs in the 3' UTR, shedding light on viral replication and translation mechanisms. doi.org/10.1099/jgv.0.… #Virology 🦟🔬