Martin Ugander

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Martin Ugander

Martin Ugander

@mugander

Physician-scientist, Professor of Cardiac Imaging @Sydney_Uni, Founder of @aecgs. 🇦🇺🇺🇸🇸🇪 I now post on 🦋Bsky about 🫀 imaging 🧲🔊 ⏺ ☢️ &⚡️ECG

Sydney, Australia Katılım Mart 2011
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Linda Johnson
Linda Johnson@lsjMD·
This is worth a trip to blue sky for. Martin Ugander is brilliant and his calculations are highly relevant and very interesting! They strengthen the case for our study conclusions and I’m glad to get to see the work from a different, clever angle. nature.com/articles/s4159… @PHRIresearch @lunduniversity @NatureMedicine
Martin Ugander@mugander

Welcome over to see my post on "How to report methodological superiority of a diagnostic test." bsky.app/profile/mugand…

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Martin Ugander
Martin Ugander@mugander·
@ProfDFrancis @rajkumar_chris @drjohnm @rallamee @bnallamo Thanks Darrel. It doesn't look like subtraction anxiety was at work. Rather, "TAVR within the first 6 months" was one of the endpoints. That seems to explain the drastic change in slope - and the entire 'positivity' of the trial(!) x.com/mugander/statu…
Martin Ugander@mugander

@rajkumar_chris @drjohnm Perhaps not subtraction anxiety. Apparently TAVR within 6 months of randomization was a pre-defined 'unplanned CV hospitalization', which convincingly explains the inflection point at 6 months. h/t @AndreasRck2 twitter.com/AndreasRck2/st…

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Martin Ugander
Martin Ugander@mugander·
I have joined the 🦋 where the sky is blue. Giving it a try. Join me.
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Martin Ugander
Martin Ugander@mugander·
Great work on #ECV #WhyCMR in mod or severe asymp #AS led by HJ Lee & SP Lee w @bernhard_gerber, Gerry McCann, Marc Dweck, @PPibarot ✅ ECV did not assoc with AS severity ✅ ECV independently assoc w outcomes ➡️ AS is about myocardium, not just the valve!
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Martin Ugander
Martin Ugander@mugander·
Our recent paper: Iyer, et al. 🫁Lung water density is⬆️in pts at risk of 🫀 failure and is largely independent of conventional #WhyCMR measures. EHJ-IMP, 2024 Is now 🔥 discussed (15 mins) by @Nithiniyer on the EHJ-IMP podcast #b1187faa82d209b2d662" target="_blank" rel="nofollow noopener">academic.oup.com/ehjimp/pages/p…
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Martin Ugander
Martin Ugander@mugander·
@rajkumar_chris @drjohnm Perhaps not subtraction anxiety. Apparently TAVR within 6 months of randomization was a pre-defined 'unplanned CV hospitalization', which convincingly explains the inflection point at 6 months. h/t @AndreasRck2 twitter.com/AndreasRck2/st…
Andreas Rück@AndreasRck2

@DFCapodanno The study result was almost entirely driven by TAVR within 6 mo in the conservative arm, which was included as unplanned hospitalization (!). That's why the curves look so strange with the inflection point at 6 mo. Not sure this is enough to tilt the guidelines.

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Christopher Rajkumar
Christopher Rajkumar@rajkumar_chris·
I think so, what else explains an initial high event rate which then subsides (aortic stenosis doesn’t get better!)? Great if you can manage the first 6 months of subtraction anxiety - event rate then tracks the TAVR arm. Psychology so important in clinical trials. @drjohnm
Martin Ugander@mugander

@rajkumar_chris @drjohnm @ProfDFrancis @rallamee @bnallamo Thanks @rajkumar_chris for chiming in. For us new to the concept of subtraction anxiety: Is the suspiciously pointy corner (immediate change in slope) of the panel A&D yellow curve just before 0.5yr a finding that is pathognomonic for subtraction anxiety?

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Christopher Rajkumar
Christopher Rajkumar@rajkumar_chris·
@drjohnm Beautiful example of the problem. Huge jump in unplanned hospitalisation immediately following randomisation that later settles = patients and cardiologists worried about their randomisation arm! @ProfDFrancis @rallamee @bnallamo
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Preeti Cho
Preeti Cho@preeti_cho·
@mugander I thought you previously had a link with a list of these
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Martin Ugander
Martin Ugander@mugander·
Friends don’t let friends submit to journals published by MDPI or Frontiers.
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Alberto Cereda
Alberto Cereda@AlbertoCereda1·
75% of right ventricular systolic function depends on longitudinal function
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