Paul Cobine

"Cancer cells don’t quickly adapt or rewire this copper dependency, which creates a therapeutic window. By introducing a copper chelator, we can dampen the MAPK signaling that tumors rely on for growth." —@bradylabupenn, @jbiolchem associate editor ow.ly/hVCN50VQpfS

@jesspatho36 @Michelle_Heck1 @CornellAgriTech @CornellCALS Congratulations!!!

"Great job. Congratulations." With final words from my committee - I passed my PhD defense!!! I'm so grateful for my amazing committee and friends who endlessly supported me 24/7. We missed you, Michelle, for the photo shoot, so I drew you in XD;;. @Michelle_Heck1

A study published today in @AppEnvMicro shows that calcium plays a significant role in enhancing the resistance of potato plants to bacterial wilt: asm.social/1Qg

Our new preprint is here! A great collaboration work with Paul Cobine @munchie37 ! @marcel_m86, Gabi Mediavilla y Xinju !!

OUT NOW!!! My latest paper with the Kornfeld lab, Lysosome-related organelles contain an expansion compartment that mediates delivery of zinc transporters to promote homeostasis. A 🧵 pnas.org/doi/10.1073/pn…

COQ4 is required for the oxidative decarboxylation of the C1 carbon of coenzyme Q in eukaryotic cells cell.com/molecular-cell…

Dual regulation of SLC25A39 by AFG3L2 and iron controls mitochondrial glutathione homeostasis: Molecular Cell cell.com/molecular-cell…

The ARC is pleased to appoint Professor Alastair McEwan as Executive Director for Biological Sciences and Biotechnology. Professor McEwan brings a wealth of knowledge and real-world experience to promote Australian research excellence. Read more: ow.ly/vhin50Q5i9A

Please RT and tell your biochemistry/molecular biology/chemical biology/neurobiology/neurochemistry postdocs to apply! We will also welcome applications from established investigators who are looking for a new opportunity. ⤵️⤵️⤵️

... and here the paper, a milestone for the field! Manipulating mitochondrial electron flow enhances tumor immunogenicity | Science science.org/doi/10.1126/sc…

Department of Biological Sciences at @AuburnU is hiring an Assistant Professor specializing in Physiology. Link for more information and to apply: auemployment.com/postings/40833

"Lactate modulates iron metabolism by binding soluble adenylyl cyclase" cell.com/cell-metabolis…

Check out our @nchembio News & Views w/@christhechang highlighting a recent @Nature study describing how copper ions drive inflammation via a mitochondrial signaling pathway that regulates epigenetic states of immune cells. nature.com/articles/s4158…

The title says it all: Human cells experience a pulse of zinc in early G1 (doi.org/10.1016/j.celr…). Using fluorescent reporters, long term imaging, and computational image analysis, @AnanyaRakshit4 and @samholtzen quantify free zinc in naturally cycling cells.

Pathogenic forms of the ANT1 protein lead to harmful consequences in yeast and mice by clogging the channels that allow mitochondria to import proteins. elifesciences.org/digests/84330/…

A new Science study in Trinidadian guppies shows that females that mate with males with uncommon traits have “sexy” sons who go on to sire higher numbers of offspring per month than their counterparts. Learn more: scim.ag/2pX

New lab preprint. Congratulations Cris for your first first-author submitted manuscript. Nodule-specific Cu+-chaperone NCC1 is required for symbiotic nitrogen fixation in Medicago truncatula root nodules biorxiv.org/content/10.110…

Thanks to a collaboration between @BiochemMetal @unistra and the group of Prof. Silvia Morante @unitorvergata, we characterized a key redox intermediate of the Copper-Amyloidβ complex by XAS at @esrfsynchrotron. Now Open Access in @angew_chem onlinelibrary.wiley.com/doi/abs/10.100…

Congratulations Vishal! It was a pleasure working with your group. FDX1-dependent and independent mechanisms of elesclomol-mediated intracellular copper delivery | Proceedings of the National Academy of Sciences pnas.org/doi/10.1073/pn…

Glad to announce that our preprint work about the type IV pilus of Xylella fastidiosa is now available as a peer-reviewed manuscript at PLoS Pathogens! journals.plos.org/plospathogens/… @LeonardoDeLaF12 @nehapotnis @munchie37