Toni Beltran

@AthiNaganathan @BenLehner Thanks!! More to come... 🧬🧬🧬🧬🧬

I don't think even computational methods can match the scale of this work! Awesome 😍 @BenLehner @mutatoni

Introducing Human Domainome v1, the largest and most comprehensive library of human protein variants to date, which maps the effects of +500K mutations across 522 domains. The study by @BenLehner and Toni Beltran @mutatoni is out in @Nature. ✍️ Illustration by @QueraltTolosa

@Albacorp7 Gràcies Alba!! Si passes per Barna avisa eh?! :P

Qué pasada @mutatonics !

The genetic architecture of protein stability by @aj4re @ainamartiaranda @cristonah @ToniBeltran13 @JoernSchmiedel nature.com/articles/s4158… @CRGenomica @sangerinstitute @ALLOXbio

Excited to share @AlbertIltirda's randomisation of protein cores at scale: Genetics, energetics and allostery during a billion years of hydrophobic protein core evolution with @aj4re @CRGenomica @sangerinstitute biorxiv.org/content/10.110…

How do chromatin modifications quantitatively impact gene expression? How do sequence variants or combinatorial marks influence relationships? We developed a modular #EpigenomeEditing toolkit to systematically test these Q, published today 🧵… nature.com/articles/s4158…

The gut microbiome influences metabolites, hormones and immune function Perturbing gut microbiota therefore impacts homeostasis across somatic tissues Could it also affect the reproductive system - and even offspring? See our results👇& tweetorial🧵 rdcu.be/dGpoc

@AthiNaganathan @biorxiv_biophys @LindorffLarsen Thanks for sharing! We will definitely include a discussion in the revised version 😊

@biorxiv_biophys @LindorffLarsen Nice to see the exponential distance-dependence of various parameters we had originally noted including the functional form. Conveniently not cited or discussed though. 🤷 pubs.acs.org/doi/10.1021/ac…

The allosteric landscape of the Src kinase biorxiv.org/cgi/content/sh… #biorxiv_biophys

@ToniBeltran13 @CRGenomica @sangerinstitute That's the Src kinase domain alone. Here's the allosteric map of the kinase domain in the context of the full-length protein (+ SH2, SH3, SH4 etc).

Thread by @ToniBeltran13 about the Src kinase allosteric map. And here is one view of the map. @CRGenomica @sangerinstitute

I'm super grateful to have had the support of all the Lehner lab members, and of course of @aj4re and @BenLehner. We are super excited to expand this approach to other kinases and enzymes next! 🧬🧑‍🔬💻

This complete allosteric map also allows us to take an unbiased look at the surface of the kinase. Many surface pockets are enriched in inactivating allosteric mutations, and we think these might be interesting sites to target with drugs in the future! 💊

I’m super happy to finally share what I have been up to the last few years at the @BenLehner lab in Barcelona! We made lots of double mutants on the kinase domain of Src to study allosteric communication.

Excited to share a new, MUCH IMPROVED version of our deep indel mutagenesis (DIM) manuscript: biorxiv.org/content/10.110… See the thread below for details.

@PSarkies Thanks a lot Peter! deep epimutational scanning next? 😜