Kay Research Group

83 posts

Kay Research Group

Kay Research Group

@mwkaylab

Matthew Kay's research group at GWU develops new ways to study cardiac physiology, with emphasis on mitochondrial function, electromechanics, & neurocardiology.

GWU Dept of BME Katılım Eylül 2014
186 Takip Edilen153 Takipçiler
Kay Research Group
Kay Research Group@mwkaylab·
@emilia_entcheva Congrats Julie! Love the Ca2+ vs. Vm phase plots, they provide unique insight into electromechanical coupling.
English
0
0
3
89
Emilia Entcheva
Emilia Entcheva@emilia_entcheva·
Overall, CRISPRi effects are mild, but specific. Full 96well plate imager with optogenetic pacing and sensing - paper out soon. We dig more into Zim3-KRAB-dCas9 in a separate brief report (not out yet). Heroic efforts by Julie over several years!
English
1
0
5
256
Emilia Entcheva
Emilia Entcheva@emilia_entcheva·
Dr. Julie Han's paper is posted: We explored #CRISPRi in already differentiated human iPSC-CMs using all-optical electrophysiology and targeting ion channels, KCNH2, KCNJ2, GJA1. Zim3-KRAB-dCas9 effector is interesting. biorxiv.org/content/10.110…
Emilia Entcheva tweet media
English
1
1
12
1.3K
Kay Research Group
Kay Research Group@mwkaylab·
In working on this creative project I learned a tremendous amount about cell culture, microfluidics, and cellular oxygenation, all thanks to my BME colleagues Emilia, Zhenyu, and our students! @emilia_entcheva @gwengineering
Emilia Entcheva@emilia_entcheva

Just submitted - @weizhen_li, collaboration w/ Z. Li and @mwkaylab. High-throughput optical sensing of peri-cellular oxygen in cardiac cells: system characterization, calibration, and testing biorxiv.org/content/10.110… peri-cellular oxygen in iPSC-CMs in 96w.

English
0
1
4
557
Kay Research Group
Kay Research Group@mwkaylab·
Very excited to announce the work of recently graduated GW BME student Dr. Jeannette Rodriguez is published in AHA Hypertension! doi.org/10.1161/hypert… @KathrynSchunke @HyperAHA @gwbiomed @gwengineering @GWSMHS
Hypertension@HyperAHA

Activation of #oxytocin neurons in the hypothalamus of rats reduces hypertension and improves #heart function during chronic intermittent #hypoxia, a model of #ObstructiveSleepApnea @mwkaylab @KathrynSchunke ahajournals.org/doi/10.1161/HY…

English
1
3
6
918
Kay Research Group
Kay Research Group@mwkaylab·
MITO ALERT! Thank you Dr. Sarah Kuzmiak-Glancy for your amazing talk and visit with us yesterday! We learned a ton about mito energetics, heart failure and sex differences! Very inspiring work!! @MightyMitoProf @UMDPublicHealth
Kay Research Group tweet media
English
1
1
8
0
Kay Research Group
Kay Research Group@mwkaylab·
@RipplingerLab Crystal - yes! I was vacationing at the beach 8 yrs ago and had the same idea and quickly discovered that you had already done it. Nice work!
English
0
0
2
0
Kay Research Group retweetledi
Sarah Kuzmiak-Glancy
Sarah Kuzmiak-Glancy@MightyMitoProf·
Cardiac mitochondrial ROS production rate cannot be directly predicted from mitochondrial driving forces following ischemia. Happy to share our open access publication in AJP Heart & Circulatory Physiology! @brianglancylab @mwkaylab doi.org/10.1152/ajphea…
English
0
3
22
0
Nikki Gillum Posnack
Nikki Gillum Posnack@NikkiPosnack·
Thrilled to participate in this "Getting it Right" mini-review on excitation-contraction uncoupling, which includes best practices based on collective experiences of @mwkaylab @RipplingerLab @lswift70. journals.physiology.org/doi/abs/10.115… @ajpheartcirc
Nikki Gillum Posnack tweet media
Crystal Ripplinger@RipplingerLab

Hey cardiac mappers: Check out our "Getting it Right" mini-review on the metabolic effects of EC uncoupling and suggested best practices. Hope you all find it useful. Thanks @NikkiPosnack & @mwkaylab for inviting me to work on this - it was fun!

English
2
3
24
0
Kay Research Group
Kay Research Group@mwkaylab·
Greatly enjoyed working with Emilia @emilia_entcheva on this comprehensive review of incredible pioneering work in #cardiac #optogenetics over the past decade. Please take a look: nature.com/articles/s4156…
Emilia Entcheva@emilia_entcheva

It was fun working on this review with Matt @mwkaylab, covering the opportunities #optogenetics has brought to the #heart since 2010, when first used by @huiskenlab, P. Sasse, T. Bruegmann, O. Abilez, D. Pijnappels and several other labs including mine.

English
0
0
2
0

Keşfet

@MightyMitoProf @emilia_entcheva @KathrynSchunke @HyperAHA @gwbiomed @GWSMHS @RipplingerLab @CarolRemme