Narayanan Lab

#cppc2024!

@aldridge_lab @MatthewWeberPhD @OdayHalhouli @johnsonpumc @geerling_lab @kalps_gupta @HAbdelmotilib Nice work!

Excited to share this prize with Dr. Weber! An important shout out to all of the co-authors that worked on this across multiple years. Thank you all! journals.sagepub.com/page/pkn/news/…

Excited for this webinar on Computational Properties of the Prefrontal Cortex from the Journal of Neuroscience: neuronline.sfn.org/scientific-res… @SfNtweets

Our latest paper showing that a few minutes of EEG can predict mortality in PD is now up: sciencedirect.com/science/articl…

Our lab's posters at SFN @SfNtweets Saturday PM and Tuesday - see you there!

Congrats to Alexandra Bova on winning a BBRF Young Investigator Award!

Our issue on Computational Properties of the Prefrontal Cortex is now: jneurosci.org/content/45/37?… These articles capture some of the incandescence of the CPPC conferences... narayanan.lab.uiowa.edu/home/cppc2024 cppc.web.ox.ac.uk accl.psy.vanderbilt.edu/blog/2018/10/1… Next one in Toronto in ~2026!

D1FLP mice are now available from JAX! jax.org/strain/039507 Detailed in this paper: pubmed.ncbi.nlm.nih.gov/39701542/ Let us know if they work for you...

Our latest paper predicting PD mortality from ~2 minutes of resting-state EEG : medrxiv.org/content/10.110…

Credits go to my world-class team. I am especially grateful to my mentors who inspired and supported/funded my academic curiosity. Our goal remains: to bridge the gap to human studies and better understand the link between neurophysiology and subjective experience ❤️

Our latest work: biorxiv.org/content/10.110… We show that corticostriatal ramping activity can't readily be explained by movements using motion tracking, and that ramping can't readily be explained by reward anticipation in mice performing timing and Pavlovian tasks.

@NadjaGingJehli with @rachelclarkcole and @JimCav

@NadjaGingJehli Our work from a great collaboration now out at Brain Stimulation: doi.org/10.1016/j.brs.… We find that 4 Hz STN stimulation in *humans* changes decision thresholds: Data: narayanan.lab.uiowa.edu and osf.io/hsz3u

Excited to share our new paper: whether STN stimulation increases impulsivity depends on theta frequency. 🧠🤓 Grateful to have contributed alongside such a fantastic team (on bluesky). Link here too: 👇 sciencedirect.com/science/articl…

Write-up of our amphetamine paper: psypost.org/amphetamine-sc…

another new preprint from our group on predicting cognitive changes in PD from resting state fMRI: medrxiv.org/content/10.110… Led by @BrookeYeagerMS!

Our latest preprint: biorxiv.org/cgi/content/sh…

@AMahajanMD Great ?. Amphetamine increases (worsens) precision, at least in timing tasks. We have a prefrontal correlate. This is systemic - we can consider local drug infusions next...and find the exact cellular correlates!

@narayananlab Thanks for sharing. Would you expect most (all?) stimulants to improve precision?

Our work showing that amphetamine affects behavior by degrading prefrontal temporal variability is now out at Neuropharmacology: doi.org/10.1016/j.neur… Work by Matthew Weber @MatthewWeberPhD As always, data and code at: narayanan.lab.uiowa.edu/datasets

And we know the temporal code in prefrontal cortex – it’s ramping activity. Surprisingly, ramps didn’t change in slope, but became more variable! Lots more details in the paper. This paper challenged our fundamental view of what we think amphetamine does…

Amphetamine has been thought to reliably affect timing accuracy. We find in a meta-analysis and in our data that it actually more reliably affects precision:

New preprint from our group showing that drugs that enhance glycolysis slow neurodegeneration in Alzheimer's disease - data from yeast to humans: biorxiv.org/content/10.110… Data and Code: bit.ly/GlycolysisANDAD narayanan.lab.uiowa.edu/home/data