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narf42@narf42·19 Ara

📢 📢 📢 !!!Come and join us!! 📢 📢 📢 We are looking for a Postdoctoral Researcher with in-depth experience in next- and third-generation sequencing to help us understand the fitness landscapes of complex biomolecules! Please spread the word :) werkenbij.rug.nl/vacature/postd…

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narf42@narf42·17 Tem

Overall, our study presents the first large-scale engineering campaign of FAcDs and introduces an operationally simple selection platform that paves the way toward adapting these enzymes for the sustainable degradation of contaminating organofluorides. (5/5)

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narf42@narf42·17 Tem

Forcing populations of bacteria expressing tens of thousands of distinct FAcD-variants to utilize various organofluorides as sole carbon source, we elicited a panel of FAcD variants with improved activities and drastically altered substrate profiles. (4/5)

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narf42@narf42·17 Tem

With #PFAS and other organofluorides wreaking havoc, we set out to engineer natural defluorinases for man-made organofluorides. All credit goes to the amazing @suzanne__jansen, who has outdone herself in this project! (1/5) biorxiv.org/content/10.110…

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J. Am. Chem. Soc.@J_A_C_S

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Maximilian Gantz@MaxGantz_·27 Mar

So glad to see this out! By giving a strong fluorescence signal to read out NAD(P)H concentration, SAFRAN will greatly extend the range of reactivities comfortably assayable in droplets. This will make droplet microfluidics a much more versatile tool for biocatalyst engineering!

Fluorogenic, Subsingle-Turnover Monitoring of Enzymatic Reactions Involving NAD(P)H: a Generalized Platform for Directed Ultrahigh-Throughput Evolution of Biocatalysts in Microdroplets | JACS @hollfelderlab @Cam_Biochem @Cambridge_Uni pubs.acs.org/doi/10.1021/ja…

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narf42@narf42·11 Şub

Two weeks ago, we had a great group outing, including a city tour through Utrecht, a Mario Kart Wii tournament, and some Rock Band Wii fun! I am truly privileged to work with such a group of talented, dedicated, and smart individuals.

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Francesca Grisoni@fra_grisoni·11 Şub

🚨Open PhD positions @TUeindhoven & @univgroningen! Are you intrigued by the potential of ML+directed evolution in drug discovery (@fra_grisoni), peptide catalysis (@robpollice) or biocatalysis (@narf42)? Do you like interdisciplinary, cutting-edge research? Then apply!👇

narf42@narf42

📢📢📢The ML-GUIDE team (@fra_grisoni, @robpollice and myself) are looking for 3 PhD students, passionate about combining the directed evolution of diverse biomolecules with deep learning approaches to develop better (bio)catalysts and drugs! Pls retweet tinyurl.com/3jz97ter

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narf42@narf42·11 Şub

📢📢📢The ML-GUIDE team (@fra_grisoni, @robpollice and myself) are looking for 3 PhD students, passionate about combining the directed evolution of diverse biomolecules with deep learning approaches to develop better (bio)catalysts and drugs! Pls retweet tinyurl.com/3jz97ter

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Francesca Grisoni@fra_grisoni·21 Ara

Finally, officially open! Open #postdoc position in Organic/Medicinal Chemistry for generative #AI in Drug Discovery — join us @molecularML @TUeindhoven 💪🏻 Funded by @ERC_Research Deadline: Jan 15, 25 More info below👇 jobs.tue.nl/nl/vacature/po… Repost appreciated! 🔃

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Francesca Grisoni@fra_grisoni·16 Ara

Great news to conclude 2024! I couldn’t think of a better team than the ones and only @narf42 and @robpollice to work on this exciting project. 🚀 Cool times ahead for the collaboration between @TUeindhoven and @univgroningen!

narf42@narf42

🥳🥳🥳 Early Christmas Present for @fra_grisoni @robpollice and me! @NWOFunding awarded us €2.7 million for our NWO-XL grant "ML-GUIDE – Machine Learning-GUIded Directed Evolution for drug discovery and (bio)catalyst engineering"! Best! Consortium! Ever! nwo.nl/en/news/64-mil…

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narf42@narf42·16 Ara

Over the past 18 months, we spent A LOT of time planning, discussing, writing, fine-tuning, and WAITING. I had such a blast though and couldn't have wished for a more creative, critical (!), and dedicated team! Thrilled beyond belief that all our efforts paid off!

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narf42@narf42·16 Ara

🥳🥳🥳 Early Christmas Present for @fra_grisoni @robpollice and me! @NWOFunding awarded us €2.7 million for our NWO-XL grant "ML-GUIDE – Machine Learning-GUIded Directed Evolution for drug discovery and (bio)catalyst engineering"! Best! Consortium! Ever! nwo.nl/en/news/64-mil…

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SynBioNL@SynBio_NL·11 Ara

Porst-doctoral research position at @univgroningen in the group of Danny IncaRNAto on characterizing the role of RNA structural ensemble dynamics in driving cell fate decision. More info below. Apply before 2nd Feburary! rug.nl/about-ug/work-… incarnatolab.com

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narf42@narf42·15 Kas

@PStacko @snsf_ch @UZH_en @UZH_Science 🎉 congrats! So well deserved!

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Peter Stacko@PStacko·14 Kas

Thrilled to announce that our team received one of the only two Starting Grants in chemistry by @snsf_ch🤯Incredible achievements that stands on shoulders of the brilliant and dedicated minds in my group🙏 #HorizonEurope Ready to kick off #PROMETHEUS project @UZH_en @UZH_Science

🔒 🕯️ 📖 Generating ultra-secure #passwords and understanding the destruction of religious images in modern #democracies: these are among the many topics that the 61 researchers who have been awarded an #SNSFStartingGrant 2024 will investigate. sohub.io/737e

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Ivana Drienovska@IvanaDrienovska·3 Eki

Thrilled to share our latest review on the role of noncanonical amino acids in biocatalysis recently published @ACSChemRev! A big thanks to everyone involved @BartBrouwer7 @francdefel @RoelfesGroup & Emilia and Jan Hendrik (both @biocat_code)!!! 🎊🎊🚀 pubs.acs.org/doi/10.1021/ac…

Bart Brouwer@BartBrouwer7

Very excited to share that our review on noncanonical amino acids in biocatalysis is now out @ACSChemRev! Thank you @francdefel, @IvanaDrienovska, Emilia and Jan Hendrik for the great collaboration! @RoelfesGroup @StratinghInst pubs.acs.org/doi/10.1021/ac…

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Bart Brouwer@BartBrouwer7·28 Eyl

Very excited to share that our review on noncanonical amino acids in biocatalysis is now out @ACSChemRev! Thank you @francdefel, @IvanaDrienovska, Emilia and Jan Hendrik for the great collaboration! @RoelfesGroup @StratinghInst pubs.acs.org/doi/10.1021/ac…

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narf42@narf42·13 Eyl

😍🙌🎉 Witnessing a PhD student become an outstanding scientist is the greatest honor for any supervisor. Last week, the amazing @Titi_a93 defended her PhD thesis in style! Listening to her answering challenging questions on cyclic peptides with ease made me beyond proud!

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