Shuchen Luo

802 posts

Shuchen Luo

Shuchen Luo

@nemo08061

4th-year PhD Candidate @ChemistryMIT & @broadinstitute. BSc Chemical Biology 21’ @Tsinghua_Uni, Beijing

Katılım Ağustos 2012
910 Takip Edilen278 Takipçiler
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Shuchen Luo
Shuchen Luo@nemo08061·
CAST enables physical alignment of spatial omics data across replicates, techs, modalities at single-cell resolution. Such accurate alignment enables spatial atlas searching, unbiased DEG identification, and reconstruction of spatial multi-omics. DM for questions and collabs!
Nature Methods@naturemethods

With the growing availability of spatial omics data from different techniques, CAST offers a computational tool for reconstructing single-cell multi-omic profiles and downstream analysis in a spatially resolved manner. @WangXiaoLab nature.com/articles/s4159…

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Itai Yanai
Itai Yanai@ItaiYanai·
My guidelines for exploratory data analysis
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Hongyu Chen
Hongyu Chen@HongyuChenChem·
Synthesizing RNA can be as fun as LEGO puzzles! This work is co-led by my incredible colleagues @LDangliang and @AbhiAditham . Huge thanks to my supervisor @WangXiaoLab for such amazing ideas. We are also grateful for the editor, reviewers, and all collaborators along the way.
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Nature Biotechnology@NatureBiotech

Chemical and topological design of multicapped mRNA and capped circular RNA to augment translation go.nature.com/47EXbfq

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Xiao Wang
Xiao Wang@WangXiaoLab·
Chapter 2 of branched RNA: chemically modified branched cap for multi-capped mRNA and capped circular RNA (QRNA)--the cellular translation machinery is surprisingly tolerant of unnatural structures! Beyond enhanced performance, the mechanism is intriguing: rdcu.be/dUQKX
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Hongyu Chen@HongyuChenChem

Synthesizing RNA can be as fun as LEGO puzzles! This work is co-led by my incredible colleagues @LDangliang and @AbhiAditham . Huge thanks to my supervisor @WangXiaoLab for such amazing ideas. We are also grateful for the editor, reviewers, and all collaborators along the way.

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Xiao Wang
Xiao Wang@WangXiaoLab·
Happy to share CAST as the "BLAST" tool for spatial omics, searching and aligning similar patterns across datasets while revealing their differences with prototype demo of querying new data against reference spatial atlas and comparative spatial studies👇rdcu.be/dULBj
Shuchen Luo@nemo08061

CAST enables physical alignment of spatial omics data across replicates, techs, modalities at single-cell resolution. Such accurate alignment enables spatial atlas searching, unbiased DEG identification, and reconstruction of spatial multi-omics. DM for questions and collabs!

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Xin Sui
Xin Sui@xsui98·
Excited to share Deep-STARmap and Deep-RIBOmap! We enabled spatial transcriptomic and translatomic mapping of >1K genes in 200 µm thick tissue and neuron morphology co-profiling. Thanks @WangXiaoLab for unwavering support; Jennifer for human skin study! biorxiv.org/content/10.110…
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Manolis Kellis
Manolis Kellis@manoliskellis·
The field of #ComputationalBiology has changed dramatically in the last few years with #GenerativeAI. I'm excited to be recording my lectures again this year, and to be teaching with the awesome @EjAlm. You can find the first lecture here: youtu.be/1zZSPeKGRzw and more will be coming in the playlist below. Fall 2024: youtube.com/playlist?list=… Spring 2021: youtube.com/watch?v=0jWOZo… Fall 2020: youtube.com/watch?v=CTPs5H… #CompBio #DeepLearning #MachineLearning #Genomics #Therapeutics #RepresenationLearning #Chemistry #ProteinFolding #ClinicalRecords #SingleCell
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Manolis Kellis@manoliskellis

Today was my last lecture for @MIT #ComputationalBiology: #Genomes, #Networks, #Evolution, #Health. I recorded each and immediately posted online here: youtube.com/playlist?list=… Please do share, and let me know which topics need more explanations, clarifications, and corrections!

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Shuchen Luo
Shuchen Luo@nemo08061·
CAST enables physical alignment of spatial omics data across replicates, techs, modalities at single-cell resolution. Such accurate alignment enables spatial atlas searching, unbiased DEG identification, and reconstruction of spatial multi-omics. DM for questions and collabs!
Nature Methods@naturemethods

With the growing availability of spatial omics data from different techniques, CAST offers a computational tool for reconstructing single-cell multi-omic profiles and downstream analysis in a spatially resolved manner. @WangXiaoLab nature.com/articles/s4159…

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Nature Methods
Nature Methods@naturemethods·
With the growing availability of spatial omics data from different techniques, CAST offers a computational tool for reconstructing single-cell multi-omic profiles and downstream analysis in a spatially resolved manner. @WangXiaoLab nature.com/articles/s4159…
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Molecular Cell
Molecular Cell@MolecularCell·
Online Now: Spatial omics advances for in situ RNA biology dlvr.it/TD8Y9t
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Cian
Cian@CianSU·
I'm excited to share our latest preprint! We've been working on a tool to bridge the gap in capabilities of existing RNA editors. biorxiv.org/content/10.110…
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Jingjia Liu
Jingjia Liu@ljjchem·
It has been a great pleasure working on this project in which the the initial idea came from creative insights on a protein structure. Huge thanks to @HaotianDu4, Possu and everyone❤️❤️❤️
Possu Huang Lab@PossuHuangLab

Exciting new work from our lab describing a novel platform for MHC-II recognition, called TRACeR, that uses just a single loop! Congratulation to @HaotianDu4, @ljjchem, and the team biorxiv.org/content/10.110…

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Nancy Zhang
Nancy Zhang@NancyZh60672287·
How do we uncover cell-cell interactions from #SpatialTranscriptomics data? Excited to share Niche-DE (doi.org/10.1186/s13059…). Niche-DE asks how does a cell’s transcriptome depend on its spatial neighbors, by identifying Niche-Differentially Expressed genes. 1/9
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Hailing Shi
Hailing Shi@HailingShi·
Thrilled to see our work finally online! We utilized in situ spatial transcriptomic method STARmap PLUS to map 1.09 million cells in the adult mouse central nervous system at molecular resolution and identified previously unknown tissue architectures. nature.com/articles/s4158…
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Nature Methods
Nature Methods@naturemethods·
Love napari but missing some ImageJ functions? Look no further than napari-imagej, which provides an accessible and comprehensive solution to ImageJ ecosystem access from napari. nature.com/articles/s4159…
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Keşfet

@LDangliang @AbhiAditham @WangXiaoLab @EjAlm @MolecularCell @HailingShi @USBrainAlliance @Nature