Nucleobased

@JMaraganore Great! As separate injections, 1 single mix or dual siRNA construct/conjugate?

Corsera is predicting lifetime risk of ASCVD with KLOTHO HEALTH, an AI-enabled tool PLUS Preventing ASCVD with a once-annual RNAi medicine targeting both PCSK9 for LDL reduction and Angiotensinogen for blood pressure lowering

I’m super excited to launch Corsera Health with Clive Meanwell and a team of pioneers committed to CV prevention! businesswire.com/news/home/2025…

🚨 Preprint alert 🚨 We have developed an entirely new mechanism of action for ASO gene knockdown -> lysosomal trafficking 🧬! Works with non-DNA ASOs (unlike RNase H mech) and higher activity than corresponding gapmers! Led by @disha_kashyap_ @UCLChemistry @OxfordChemistry

We're seeking postdocs with a background in chemical biology, especially synthesis and screening. RNA expertise is a plus, but we'll train you! We Offer. Dynamic team environment; Opportunities to broaden your horizons in RNA biology. Part of a new RNA Center. Mdisney@ufl.edu

Interesting read: Intravenous administration of blood–brain barrier-crossing conjugates facilitate biomacromolecule transport into central nervous system #Oligonucleotides nature.com/articles/s4158…

Great read: SCAD Delivery Platform: A Novel Approach for Efficient CNS and Extrahepatic Oligonucleotide Therapeutics #Oligonucleotides biorxiv.org/content/10.110…

Great read: Synthesis of 2′-formamidonucleoside phosphoramidites for suppressing the seed-based off-target effects of siRNAs #Oligonucleotides academic.oup.com/nar/article/52…

Interesting read: Mechanistic Insights into ASO-RNA Complexation: Advancing Antisense Oligonucleotide Design Strategies #Oligonucleotides biorxiv.org/content/10.110…

Interesting read: A Unified Phosphoramidite Platform for the Synthesis of Morpholino Oligonucleotides and Diverse Chimeric Backbones #Oligonucleotides pubs.acs.org/doi/10.1021/ja…

Interesting read: Safety and effectiveness of interference RNA (RNAi) based therapeutics in cardiac failure: A systematic review #Oligonucleotides sciencedirect.com/science/articl…

Very helpful tool when working with Oligonucleotides!

Interesting read: Structure – silencing duration relationships in RNAi medicines in rapidly dividing cells #Oligonucleotides biorxiv.org/content/10.110…

Great read: Improved In Vivo Metabolic Stability and Silencing Efficacy ofs iRNAs with Phosphorothioate Linkage-Free, GalNAc-Conjugated Sense Strands Containing Morpholino-LNA Modifications #Oligonucleotides pubs.acs.org/doi/epdf/10.10…

Interesting read: Chemical Synthesis of Modified RNA #Oligonucleotides onlinelibrary.wiley.com/doi/10.1002/an…

Interesting read: Overcoming limitations and advancing the therapeutic potential of antibody-oligonucleotide conjugates (AOCs): Current status and future perspectives #Oligonucleotides sciencedirect.com/science/articl…

Interesting read: Modular and automated synthesis of oligonucleotide-small molecule conjugates for cathepsin B mediated traceless release of payloads #Oligonucleotides sciencedirect.com/org/science/ar…

Interesting read: Precision targeting in oncology: The future of conjugated drugs #Oligonucleotides sciencedirect.com/science/articl…

Interesting read: "Synthesis and validation of clickable multimeric mannose ligands for dendritic cell targeting" #Oligonucleotides #d1e778" target="_blank" rel="nofollow noopener">tandfonline.com/doi/full/10.10…

Interesting read: "Mechanistic insights into ASO-RNA complexation: Advancing antisense oligonucleotide design strategies" cell.com/molecular-ther… #Oligonucleotides

Learning time: Protocol to generate, purify, and analyze antibody-oligonucleotide conjugates from off-the-shelf antibodies #Oligonucleotides sciencedirect.com/science/articl…

@JMaraganore @Alnylam Thanks John, in your continued believe in the modality. It has and will continue to serve many patients to come as well as excite and support many current and future Scientists and their families in this exciting space!

Such an honor to receive the Lifetime Achievement Award from OTS! I’m so grateful to my colleagues at ⁦@Alnylam⁩ who worked with me to pave the way for #RNAitherapeutics! Now excited about the next generation with City!