
Ruth V. Nichols & Brendan L. O'Connell
46 posts

Ruth V. Nichols & Brendan L. O'Connell
@oconnellphds
Husband & wife PhD duo working on single-cell epigenomics at Oregon Health & Science University with @acadey80. Ruth maintains the account.




sciMET v3, an interesting method for large-scale single-cell methylation study presented by Andrew Adey. Using combinatorial indexing and methyl region capture they can now generate meth profile for 10^5 cells. #AGBT24



OHSU Researchers Push Throughput, Accessibility for Single-Cell Epigenetic Assays. An improved sample prep workflow for single-cell methylation analysis offers the prospect of commercialization, which could be readily taken up in cancer genomics. ow.ly/6NBa104wCnV



1/6 Very excited to announce sciMETv2 for high-throughput robust single-cell DNA methylation analysis led by @oconnellphds out in @NatureComms! #SingleCell @OHSUBrain @OHSUKnight @OHSUNews @OHSUSOM #epigenetics rdcu.be/c1kdp




Our recent work on developing "s3" as a means of achieving increased unique read counts per cell for transposase based assays came out today! Led by Ryan Mulqueen along with an excellent team of collaborators. nature.com/articles/s4158…




