Odoreida

@bouguereau_stan @greegle_mudzone *purged here means eliminated from the population over time

@bouguereau_stan @greegle_mudzone yeah mutations accumulate, some of them have effects on molecular stuff - if this effect isn’t too bad *at the level of the organism* and its population size is small these will tend to accumulate. Really bad ones will be purged tho

i watched many millions of €$£ wasted cataloging transcript variants and got from awkward silence to ‘shut up if you know what’s good for you’ back when i raised this but the worst of it is that the people who pushed all this are now embedded as ‘research leaders’. ship of fools

@greegle_mudzone you can’t get a directeur of research to understand this when his horizon2020 grant depends on him not understanding it

@odoreida Intelligent design? The genome's full of pencil shavings and crumpled receipts like the footwell before a metrocar seat.

@_heral_fog no idea, just the day never goes well after a sighting

@odoreida why are the stoats inauspicious

[striking up conversation] have you seen any auspicious fauna lately

@greegle_mudzone they are different mRNA forms from the same gene due to use of different exons, starting points or ends. big consortia mapping all of these on the basis that they will then ‘find out what this complexity is for’ (nothing, mostly)

@odoreida What is going on here? Transcript variants?

wonder if i’ll see a hoopoe this year

@adam_kranz you are a most gracious host

I'm at the schizo point in my PhD arc where I look at a mosquito bite and start connecting dots like I'm seeing the underlying pattern finally come together

@TonklinDiary excellent porkiness at front half

my Effort

@TonklinDiary @norvid_studies came out a grice

@odoreida @norvid_studies so many pigs and so few hams

@BamaExpat #1 pov: ur wife is beginning to suspect that u are not one of the elect

“You must choose one of our folkways, anon.”

@RollingHedge @RegHumber @TheFuzzyPirate Any thoughts on agricultural/amenity land? Prob depends on future subsidy regimes..

Understand your impulse here, but let me explain… Gold: The fiscal arithmetic across the developed world is, to borrow from the engineers, path-dependent in exactly one direction, and it is not the direction that ends well for anyone holding nominal claims on insolvent sovereigns. The US is running 6-7% deficits at full employment with no political constituency for consolidation. Britain is grinding north of 100% debt to GDP with a gilt market whose plumbing is already creaking under issuance volumes the buyer base cannot absorb at current yields (I’ve written quite extensively about his topic). Japan is the cautionary tale everyone cites and nobody learns from. France is next. The central banks of the non-aligned world have drawn the obvious conclusion - reserves held in Western sovereign debt are not reserves but hostage capital, confiscable at Washington’s discretion, as Moscow discovered in February 2022. The PBOC, the RBI, Ankara, Riyadh, and the Gulf states are all accumulating gold at a pace that is price-insensitive, structural, and nowhere near finished. Gold’s behavioural regime has shifted accordingly - no longer counter-cyclical insurance but pro-cyclical with fiscal expansion, because when governments are the marginal source of demand the denominator degrades faster than the numerator improves. Mechanical re-rating to reflect cumulative monetary debasement since 2008 gets you to $7-8k easily. A genuine confidence event in any major sovereign bond market - and the candidates are multiplying - overshoots to $10-11k and beyond within a 5-15 year window that is, frankly, generous. Bretton Woods III is no longer a theory for my money. London property: boomers will be dying, and the property market they inflated is about to discover what happens when supply meets a buyer base that does not exist at current prices. Hundreds of thousands of £1m+ properties are held by people in their 70s and 80s whose actuarial runway is 11-12 years. Estate liquidation begins in earnest in the early 2030s. The generation beneath them cannot absorb it. London prices at 12-13X median earnings, mortgage affordability capped at 4.5X income, deposit accumulation functionally impossible on median wages after London rent is paid. The professional salary pipeline that historically produced future buyers is being hollowed out by AI displacement from above and Indian IT services substitution from below, targeting precisely the mid-tier legal, compliance, and financial services back-office roles that constituted the escalator to million-pound ownership. Remote work dilutes the location premium. Foreign capital is retreating. No government has an electoral incentive to intervene. The realistic outcome is not a crash but a sustained real-terms repricing of 30-50% percent over the next decade, which is to say the market will do slowly and painfully what no politician has the courage to do quickly and cleanly.​​​​​​​​​​​​​​​​ Therefore, this is my calculus as things stand: - Gold up - Commodities / hard assets up - London property down Naturally, I welcome all counter arguments in good faith, I could be wrong and am open to hearing better ideas.

Relieved to be fully out of London property since September last year. I no longer view real estate as a viable asset class (in the near term, or even medium term, future) per se. Moreover, who will buy all the £1m+ properties nationwide when the boomers die? Median wages are several multiples lower and due to inflation no one is saving anything approaching a deposit for such a property. Smells like a bubble waiting to pop. The market will be flooded with these ‘assets’ in the next 15-20 years and the prices will have to crater unless something changes. Perhaps AI increasing wages of the new managerial class will rise to meet it. But somehow I cynically doubt it. Meanwhile, you have to live somewhere of course and our home is very much that. A home, not an asset.

A parasite will, once in the claws of its host, only retain that functionality that cannot be offloaded while maintaining survivability. A maximally embracing host, will create maximally degenerative parasites. This pattern is fundamental. It appears at every level of reality.

@cremieuxrecueil just look what woke did to the brothas. the buck got broke in 2016

Is it perhaps because of a racial composition change? No. Different races tend to have similar testosterone levels and trends within groups are similar.

Why have testosterone levels been rising over time? The testosterone levels of American men are up compared to what they used to be, but no one has a good explanation. Let's look through some possibilities🧵

@Romy_Holland An ant that size would completely eviscerate a human of that size. It's not even a competition. You might as well give up.

@norvid_studies @JohnSchoffstall @Shadoo_creeture @LucreSnooker @medjedowo @pleometric on a small field (of tissue), like the tail as compared to the body, patterns that would form spots on a large field will instead form stripes or bands (if they form by Turing type patterns) math.pku.edu.cn/teachers/litj/…

@odoreida @JohnSchoffstall @Shadoo_creeture @LucreSnooker @medjedowo @pleometric what's the morphological law there...

Why is there just a second secret evil group of felines tgat nobody ever mentions like I'm sorry wjhat the fuck is a linsang???

@greegle_mudzone @norvid_studies @Shadoo_creeture @LucreSnooker @medjedowo @pleometric The genets of spain were,iirc, though to have been pets/domestics that became feral/wild

@odoreida @norvid_studies @Shadoo_creeture @LucreSnooker @medjedowo @pleometric Why is it that long slinky carnivorans are peak cute? It's not neoteny at work. Last I checked babies of most species are not Pringles'd. Mongooses (viverrids? not checking), musteloids, they're mega cute.

@JohnSchoffstall @norvid_studies @Shadoo_creeture @LucreSnooker @medjedowo @pleometric the big point here is that whatever their actual phylogenetic relationships they all illustrate nicely how you can have spotted animals with striped tails but not vice versa

@odoreida @norvid_studies @Shadoo_creeture @LucreSnooker @medjedowo @pleometric I admit I had never heard of linsangs or genets. Looked them up. Neat!