Paul Burke

#Breaking: Health secretary RFK Jr. shuts door on U.S. investment in mRNA vaccine research statnews.com/2025/08/05/mrn…

Use of GalNAc-based liver targeting to improve the safety profile of an effective small molecule. The result of a terrific collaboration between the non-profit, academic, and industrial sectors ==>> @gatesfoundation @UWMolES @UWBioE science.org/doi/10.1126/sc…

RNA-editing drugs advance into clinical trials bit.ly/445OqZV ADAR-based editors that can change the mRNA code offer new opportunities in both rare genetic diseases and common complex ones. Find out more in this news article published today

Three cheers for intact TLR9 inflammatory signalling!

Novo's giant bet on ncRNA => statnews.com/2024/03/25/nov… via @statnews

Delivery, delivery, delivery! Join us in Siracusa, Italy from April 4-7 to discuss new advances in nucleic acid delivery and how to solve the remaining challenges! Don't miss this opportunity. Abstract deadline is March 15, 2024. Register here: #header4" target="_blank" rel="nofollow noopener">engconf.us/conferences/bi…

We are excited to share our views on extra-hepatic delivery in @NatureNano. Congrats to all our exceptional team members who did most of the heavy lifting and the editorial team and reviewers for their feedback! Happy New Year and Happy Reading! nature.com/articles/s4156…

#Breaking: The U.S. FDA approves the CRISPR/Cas9 gene-edited treatment, co-developed with Vertex Pharmaceuticals, for #SickleCellDisease. Learn more: bit.ly/4apMw9p

Approval of Casgevy, from Vertex and CRISPR Therapeutics => nature.com/articles/d4158…

“A new Nature series will explore the many ways in which artificial intelligence is changing science — for better and for worse.” nature.com/articles/d4158…

If you use the @wsj App and have not recently updated it, DON’T DO IT!!! It is the New Coke of iPad Apps. And it appears there is no way to roll back to the earlier version.😠

Alnylam’s experimental Alzheimer’s RNAi therapy cut disease-linked proteins by 65% for six months – Endpoints News endpts.com/single-injecti…

Novo Nordisk's oral semaglutide on par with injectable version in weight loss and safety - endpts.com/novo-nordisks-…

“The bottleneck used to be the science and finding drugs,” says one physician. “The new bottleneck is having enough people trained to give them.” ⁦@AmyDMarcus⁩ #antisense wsj.com/articles/these…

It’s a big mistake to weigh commercial opportunity (often done by 25 yo consultants) over likelihood of patient impact (usually done with gray hair and wrinkle)…. Just saying!

Amazing! wsj.com/articles/ozemp…

Combinatorial design of nanoparticles for pulmonary mRNA delivery and genome editing | Nature Biotechnology nature.com/articles/s4158…

Promise of superhero status makes injections acceptable! “As influencers share stories of physiological transformations, more people are seeking out experimental treatments: ‘If I can be a superhero and function at my absolute optimum, why wouldn’t I?’” wsj.com/articles/pepti…

Looking forward to digging into this, recently posted from @wittrup_anders lab => nature.com/articles/s4146…