The Area X novels (AKA the Southern Reach Series) are fascinating, but an acquired taste, surreal and unsettling. Worth a shot if you love WILDERNESS, though.
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Paul Ingraham (PainScience.com)
17K posts
Paul Ingraham (PainScience.com)
@PainSci
Highlights, updates, and skeptical snark from https://t.co/Jxovxz38Qu publisher Paul Ingraham. The salamander symbolizes healing & legit biological marvels.
Vancouver, Canada Katılım Kasım 2009
453 Takip Edilen11.2K Takipçiler
Planned to drop that into this article:
painscience.com/objectivity
And get on with my day, 5m tops. But my attention was hijacked! I rewrote that little article. So much for what I was supposed to do this morning. 😜
Sometimes I still do my job like a cat chasing a laser pointer.
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I highlight a lot of things as I read, but I almost never go back and look at what I highlighted. I finally got around to trolling through several YEARS worth of quotes, and I was rewarded with several gems like this one.
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@runliftrunlift If I ever ran without being “constantly injured,” it has been so long that I’ve forgotten what it feels like. There’s less injured and more injured … but there’s always something!
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Running is a lot more fun when you’re not constantly injured
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Many factors affect pain bothersomeness, but “intensity × duration” is arguably in a class by itself and needs emphasis.
painscience.com/blog/mild-pain…
(Upgraded yesterday’s post: better graph + a big new footnote + a nice relevant new citation I missed on the first pass.)
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@datadocluis Right?! It fits with the pattern of pain care being seriously flawed in general. I’ve written a LOT about that (full post paywalled, but there's a substantial free summary):
painscience.com/post_why_is_it…
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@PainSci We track trends for every chronic condition except pain. A 2/10 sustained for months creates a devastating cumulative burden. SPID already measures this. Why is it not standard?
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Pain isn’t actually “mild” if it never stops. Persistence can turn a small pain into a nightmare. Duration MULTIPLIES the intensity! But we try to quantify #chronicpain intensity without duration? 🤦🏻♂️
painscience.com/blog/mild-pain…
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Is a story about being “abused” at a #chronicpain clinic believable? It’s all too easy to believe: some pain rehab clinics have serious patient-blaming problems. NEW POST, 3-minute read:
PainScience.com/blog/mayo-pain…
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@KfizzSimon Well that there is an official Deep Thought® 🙂
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Every now and then I encounter someone who seems unusually keen on the idea of a whole body scan, almost worshipful, an unhealthy and unrealistic fascination, like they are on a pilgrimage to an oracle or a holy healing site.
Eric Topol@EricTopol
At @JAMA_current today, 2 radiologists publish what should be the consent form for a total body MRI in healthy people Note: "no major medical society recommends whole-body MRI screening in the general population because it is unproven, and the harms likely outweigh the benefits." jamanetwork.com/journals/jama/…
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“Maybe this pain treatment won’t work any miracles! But…every little bit helps, AMIRIGHT?”
Ackshually, not every little bit helps—not even close.
First: it may not help even a “little.”
Second: even if it does, it may not be a good VALUE…
painscience.com/blog/every-lit…
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Those who reject the alleged arrogance of authority and expertise mostly just replace it with the ACTUAL arrogance of believing they know better.
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Disturbing story. Much #chronicpain is caused by hard-to-diagnose pathologies, or by pathologies that should NOT be hard to diagnose … but get missed anyway. 🤦🏻♂️
(HSP is primarily a motor disorder, but pain is routinely involved and clinically significant.)
Keith Siau@drkeithsiau
A 23-year-old woman from Cardiff was repeatedly labelled with functional and psychiatric diagnoses including anxiety, depression, and epilepsy, despite progressive neurological symptoms. Following a seizure in April 2025 that left her in a coma for 3 days, she typed all her symptoms and medical history into ChatGPT, which generated a differential including Hereditary Spastic Paraplegia. She presented this to her GP which triggered genetic testing that confirmed the diagnosis. Hereditary Spastic Paraplegia is a genetically heterogeneous group of neurodegenerative disorders characterised by progressive lower limb spasticity and weakness. This is caused by degeneration of the corticospinal tracts, with phenotypes ranging from motor involvement to complex syndromes with ataxia, cognitive impairment, +/- peripheral neuropathy. Diagnosis relies on genomic sequencing, and management involves symptom control, physiotherapy and multidisciplinary rehabilitation. Source: BBC News
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2 new scientific reviews of cannabis for neuropathy… different conclusions about more or less the same data. Thought I’d have some good nerdy fun comparing and contrasting them.
New short post for all + audio for members:
PainScience.com/blog/two-new-r…
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@PainSci Bird, moon, water, bird moon.
I'll see myself out. 🤪
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A few highlights from a little holiday in progress. Exercising my zoom lens quite a bit. 🙂
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CAUSALITY INFERENCE is a defining feature of human intelligence that serves us well. Flick switch, light goes on…probably causally related!
But we get it wrong a LOT…especially in health/medicine. So many variables!
NEW POST (4m read, member audio):
PainScience.com/blog/actually-…
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Paul Ingraham (PainScience.com) retweetledi
Today I finished 5 weeks of a remote “gold standard pain management program” via the Tampa VA.
I’m not new to chronic pain. I found it tedious and very condescending. The overall message: Opioids bad, mindfulness good.
Hugging trees & breathing solves everything, apparently.
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Paul Ingraham (PainScience.com) retweetledi
I am getting sick and tired of these so-called pain experts discuss chronic pain and say oh these are just every day aches and pains. That is not what people with severe chronic pain experience. They’re talking about the worst acute pain you can ever imagine that is unrelenting. Stop minimizing it by calling it every day aches and pains. I’m looking at you, Rachel Zoffness.
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