PATHOLOGEEK

1. PSEUDOGOBLET CELLS. Continuous and linear pattern and lack the strong blue staining of acid mucin when stained with alcian blue. 2. TRUE GLOBET CELLS. Singly dispersed, pale gray on H&E, and due to acid mucin they turn intense blue with alcian blue stain. #GIpath

While causes of IBS are unknown, they found a positive feedback loop where 5-HT7 plays a key role. This may lead to a promising treatment using 5-HT7 antagonist which would improve the quality of life for millions of sufferers. So checkout the latest and greatest in this paper!

IBS is often diagnosed. Pain from hypersensitivity is the worst part for patients. In this paper they investigated the role of 5-HT7 receptors in mucosal innervation and intestinal hyperalgesia.

Colonic biopsies due to chronic pain are very common in Pathology labs. Chang et al describe mechanisms of hypernociception from IBD in this awesome paper: doi.org/10.1038/s41374… A must read! @DCF_path #GIpath #IBD

▪️Piet Mondrian Mondrian is known for his straight lines and pure colors, orderly and mathematical. However, some of his early works with serene landscapes reminds us of the diverse structures of neurons in the central nervous system #pathart #pathtwitter #pathology #pathologist

▪️Jackson Pollock Perhaps the greatest figure in the abstract expressionist movement. His "drip technique" is reminiscent of loose connective tissue that is stained with charcoal from a submucosal tattoo and other dyes. #pathart #pathtwitter #pathology #pathologist #GIpath

ART & PATHOLOGY From Kandinsky to Georgia O'Keeffe, it’s almost as if these artists peered into a microscope to find inspirations for some of their works. Follow the 🧵 to see similarities between these masterpieces and benign tissue samples. @DCFpath #pathart #PathTwitter

9/9 Pathologists and clinicians must be cautious of the limitations and pitfalls of morphological diagnosis and be mindful of the tests needed to make organism-specific diagnoses. #DCF_path #pathology #pathologist #PathTwitter

8/9 Hyalohyphomycetes are a diverse group with similar tissue forms, but treatments vary tremendously. Namely, Scedosporium apiospermum does not respond to Amphotericin B, but Aspergillus does. So, by stating that it’s Aspergillus, one may have misdirected the treatment.

Pathology Report for Fungal Infections #tweetorial 1/9 Histopathological diagnosis of an invasive fungal infection should be PRIMARILY DESCRIPTIVE and must include: Follow the thread to discover. 📌 The order can vary but try to include them all. #DCF_path #PathTwitter