Jacob

I hope you've enjoyed this thread! (And maybe even learned something) If you did, consider reposting it to share with friends:

Here's the full talk: youtu.be/ELcVYRJJdK4?si…

5) Getting sick destroys your NAD When coronavirus infects your cells, your immune system fires back by activating 5 members of the PARP enzyme family. PARPs are massive NAD consumers. Dr. Brenner explains this process:

4) The brain is the most vulnerable organ when NAD runs low The liver can make NAD from almost any precursor: tryptophan, NR, nicotinic acid. Neurons can't. Your brain is the last place you want an NAD shortage:

Everyone from Joe Rogan to the Kardashians swears by NAD for anti-aging and recovery. Rhonda Patrick interviewed the scientist who discovered the molecule behind it. Dr. Charles Brenner. Here's everything you need to know (thread): 1) NAD fixes damaged DNA

3) Being overweight drains your NAD When you're obese or insulin resistant, your body is constantly fighting damaging molecules. NAD gets consumed faster than your body can make it. The result: less energy, slower repair, and accelerated aging at the cellular level.

2) NAD is the wiring of your entire body Think of your body like an electric vehicle. The battery stores high-energy electrons & copper wires deliver them to every system. NAD is the copper wire (capturing electrons from food & routing them to fuel everything you do)

Every day your cells take hits from radiation, toxins, and normal metabolism. When damage happens, an enzyme called PARP-1 consumes NAD to trigger the repair process. Over time, unrepaired DNA damage is one of the main drivers of cancer.

None of this replaces medical care, especially with a neurodegenerative diagnosis. But if you're figuring out where to start with aging parents: multivitamin, vitamin D, and sulforophane are the easiest wins. Anyone else's family already on these?

Most shelf broccoli sprouts are inconsistent, and growing your own means fighting contamination. If you want the purest form, here's the one to check out (aff link): amazon.com/dp/B07V47DGTB?…

4. Ubiquinol (the active, reduced form of CoQ10) CoQ10 powers your mitochondria. Low levels are tied to mitochondrial dysfunction. Early studies in Parkinson's patients show it may help especially with tremors.

3. High-DHA omega-3 (~2g/day). Evidence links it to better dopamine signaling and brain function which is especially relevant for Parkinson's and Alzheimer's risk.

The only 5 supplements worth giving to your parents (and why each one matters): 1. Vitamin D

Result: reduced global cognitive aging by ~2 years. Episodic memory aging (remembering events in your life) dropped by 4.8 years. From a $15 bottle of Centrum Silver.

2. A basic multivitamin (yes, really). For years "experts" said multivitamins were useless. Then 3 separate randomized controlled trials tracked adults 65+ for 2 years using a standard drugstore multivitamin.

70% of the US is insufficient. Older adults are worse. Aging skin makes ~4x less vitamin D from sunlight than it did at 20 (even with the same sun exposure).