Proline-rich antimicrobial peptides are still out there combating some nasty pathogens:
doi.org/10.1021/acsinf…
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Vladimir Kubyshkin
183 posts
Vladimir Kubyshkin
@polyproline
Physical organic chemistry, fluorine, amino acids, peptides and more currently at Enamine Ltd, Ukraine
Ukraine Katılım Ağustos 2021
48 Takip Edilen75 Takipçiler
Selective targeting of the key enzyme in proline biosynthesis:
doi.org/10.1021/acsche…
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Well, this is interesting set of data. The effect of azetidine-2-carboxylic acid exposure on neuroblastoma cells.
doi.org/10.1016/j.fct.…
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Did you know that in chemistry you can ride bicycles? Very small. Really tiny. Yet, they can take you places you've never thought before.
Discover what these bicycles can do to bring us close to novel drugs in our recent review with @MykhailiukChem
pubs.acs.org/doi/10.1021/ac…
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What a sad message 😟 this used to be such a useful resource. Thank you, molinspiration team!
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Production of xenoproteins on a gram scale. The incorporated noncanonicals include fluoroprolines.
Looks pretty cool to me! 👍🏾
doi.org/10.1002/cbic.2…
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Well done to my PhD student Periklis Karamanis who has recently defended his thesis! Here is our recent work on "Synthesis of Trifluoromethylated Analogues of the Cyclic Lipopeptide Iturin A and Evaluation of their Antifungal Activity"
doi.org/10.1002/cplu.2…
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Very much enjoyed reading the newest review from Ned, Hamid and Huy on genetic code engineering. A summary of efforts, pitfalls and challenges.
doi.org/10.1002/cctc.2…
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Really impressive review article on how to improve substance's solubility AND permeability at the same time, the trait combination that the authors called Aufheben. Great summary of strategies and examples from contemporary drug design! Open access
doi.org/10.1021/acs.jm…
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Just learned that chronic Staph. aureus readjusts its metabolism to feed on proline from collagen deposits. Mindblowing!
doi.org/10.1038/s41564…
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A whole panel of 5-spirocyclic proline analogues prepared by colleagues from Enamine
doi.org/10.1039/D4OB01…
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Another amazing work from the group of JC Horng, unveiling the effects of cation-pi interactions in the assembly of the collagen triplex
doi.org/10.1021/acs.jp…
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A fold stabilizing effect of a proline analogue on a 36 residues miniprotein
doi.org/10.1038/s42004…
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Few interesting heteroatomic proline analogues in collagen mimetics. Seems that 5-oxaproline is well tolerated and accelerates the triple helical assembly. Great work!
doi.org/10.1039/D5OB00…
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Aromatic caps at the termini promote stability to triple helix in collagen mimics with just 4-6 GPO repeats
doi.org/10.1021/acs.bi…
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The importance role of central proline to the antimicrobial potency and selectivity of indolicidin
doi.org/10.1007/s00203…
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I'm not a computational chemists, but would like to thank Prof Karplus for his work on rotation around peptidyl-prolyl amide bond, where they identified the major rotation pathway, and introduced the rotation transition state nomenclature. Merci!
William L. Jorgensen@JorgensenWL
It is very sad to learn that Martin Karplus passed away on Dec 28 at age 94. He was a scholar and pioneering chemical physicist with great contributions in many areas including molecular dynamics. We interacted many times starting from my graduate time at Harvard. His legacy is reinforced by the large number of coworkers who have also done much to advance computational science.
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I got a couple of new postcards from Genova and Berlin. Thank you for the Christmas cheer, Lars!
Happy 2025, everyone! I hope for a better year for all of you. Let your efforts pay off this year, my dear friends!
🍾🥂🎄🥳
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Really good article published few months ago about the choice of linker for drug macrocyclization. Many clever ideas.
doi.org/10.1021/acs.jm…
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Here is a nice new article on fluoroproline labelling of huntingtin protein and subsequent 19F NMR:
doi.org/10.1002/chem.2…
As we speculated in our Chem Rev article, this type of labelling could make sense in proline-rich or polyproline domains, which is the case here.
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