Chris Coffey

@christen_rexing But he has to get it from an actual restaurant where the food looks a bit different than what he has in his videos

I’d actually watch that.

Stakeholders involved in Parkinson’s platform trials met for the second annual International PD-Platform Meeting. They launched the Global Alliance for Parkinson’s Platforms (GAPP), bringing together international leaders of Parkinson’s platform trials: buff.ly/RoM8laO

We are nearing the time of year when I have to pay special attention to whether I am watching a show/movie on Hallmark or ID so that I know when a girl meets a guy whether they are going to fall in love or he is going to murder her.

@ehlJAMA For the question about identifying the assigned group, isn’t the hypothesis that the answer should be correct about 50% of the time by chance if they are just guessing? So the smaller percentage is more significant because it is farther from 50% (chance).

In the more than 40 years that I’ve been a physician I’ve seen an awful lot of acetaminophen given. It’s probably one of the most benign drugs available to treat any human disease. Given its extensive use, if there were significant complications, they would’ve been apparent by now. One of the studies quoted here has this statistical analysis as its main finding Consistent with our first hypothesis that acetaminophen would increase BART risk taking, a t-test revealed a significant difference in risk taking between those on acetaminophen and those on placebo, t(140) = −2.29, P = 0.023, 95% CI [−10.94, − 0.81], Cohen’s d = 0.38 (Figure 1A, left panel). Note the huge confidence interval. Another name for this is an uncertainty interval. The amount of uncertainty in these findings is substantial and precludes any meaningful conclusions about the study. This study does not show what the authors claim it does because of this substantial uncertainty in the result. Also, they had a peculiar observation where they tested if patients in the randomized groups knew which study arm they were in. One group had about a 35% rate of correctly identifying their group. This was justly significant. Another group had about a 47% Knowledge, but this is declared not statistically significant. I don’t know how you can find a significant result based on one proportion of a population having the finding, and then when that proportion increases loose physical significance. Unless explain, this observation suggest that the statistical analysis of this study is in serious need of review. Bottom line, it is common for studies that are quoted to support arguments against commonly used pharmaceuticals, agents, chemicals, etc. are very poor quality. It is common for good science to be undermined by bad science.

Can 'light therapy' help people w/ Parkinson’s sleep better? The ENLITE-PD randomized study put this idea to the test. Aleksandar Videnovic and colleagues did a great job on this multi-center effort. Spoiler alert: bright white light therapy was not effective. Key Points: - Bright white light therapy was safe, well tolerated and had good adherence across groups. - Twice-daily light therapy showed some improvements in sleep and fatigue, however it did not meet criteria to advance to a phase 3 trial. - Once weekly bright light was non-inferior to dim red light and may serve as a better control condition for future studies. My take: I think it is critically important to put non-pharmacological therapies to the test, and I congratulate the authors for conducting this study. Right now, it looks light the ‘juice may not be worth the squeeze’ for the current versions of light therapy for Parkinson’s. Here are 5 points that resonated w/ me about this article: 1- Sleep issues frequently affect people living w/ Parkinson’s and remain a major unmet need. 2- Light therapy is safe and may help improve fatigue and aspects of sleep, however the benefits were modest in this trial. 3- Not all light therapies are the same and more research is needed to determine frequency, timing and type of light that work best. 4- This study highlights the importance of rigorous trials to sort out real benefits from placebo and also from the effects of daily rhythm. 5- Future light therapy studies will need longer durations, diverse populations and objective measures to truly understand if there is a potential we are missing. …mentdisorders.onlinelibrary.wiley.com/doi/10.1002/md… @FixelInstitute @ParkinsonDotOrg @movedisorder @SfNtweets

Great movie. I usually recommend it to students in my clinical trials course. There is a “twist” that is very relevant to some of the course discussions.

@MassGenBrigham @PaganoniMDPhD Congrats, Sabrina. Extremely well deserved

Congratulations to @PaganoniMDPhD, physician-scientist, who is the newly appointed inaugural Robert H. Brown, Jr. Endowed Chair in Neurology. Dr. Paganoni was recognized for her groundbreaking leadership in #ALS treatment and recovery.

@FadeAwayMedia LA & Punk - Yeah!!

WHAT ARE WE CALLING THIS DUO? 👀 #WWERAW

If you'll be at #JSM2025 next week, come check out some of our @Iowa_Biostat current students and faculty present their research!

The ExTINGUISH Trial Methods Paper is available, Open Access! 👉There are no approved (or rigorously studied) treatments for NMDAR Encephalitis. 👉 Enrollment is ongoing for newly diagnosed NMDAR Encephalitis patients, via NIH/NINDS & the NeuroNEXT Clinical Trial Network

Tonight is #MLBAllStarGame2025 It always reminds me of one of the most “statistician” things I did as a kid. I would keep score each year and using different color pencils for each player - with the color matching the player's team colors (red for Reds, blue for Dodgers, etc.)

@JayinSTL Title win would have been tainted a bit for Fletcher here. Rhodes likely a great choice as a transitional champion. And can drop the belt to Fletcher.

To everyone complaining about Dustin Rhodes winning the TNT Title & not Kyle Fletcher, it's a title that can be defended every week. Kyle will have his time. This show is in Texas, Dustin's home state. The emotion on his face after he won. That moment with his nephews &

Join NINDS for "Challenges in Pediatric Neuroscience Research: Bench to Bedside" with Dr. Sunny Juul & Dr. Elizabeth Berry-Kravis. July 30, 2025 | 12-1 PM ET Register now: bit.ly/3ZqgPZm

@ScienceofPD @EJS_ACT_PD @CureParkinsonsT Very exciting!

Very excited to be at the @EJS_ACT_PD annual meeting today - an extremely ambitious & exciting new multi-arm, multi-stage clinical trial platform for testing potentially disease modifying therapies for #Parkinsons - @CureParkinsonsT is proud to be one of the funders involved

@HonoraryDawg It’s also the little details. Watch Seth help with the ladder from the mat.

El Grande Americano should've won for this alone... #MITB

Just published 👉 A NEWLY updated, comprehensive meta-analysis of the treatment of anti-NMDAR encephalitis: Analysis, equipoise, and the urgent need for evidence over anecdote 🧠🔥 Why is this paper so important ? 1/

@RxRegA I like this approach in principle. In practice, I am concerned that those types of RCTs will be very difficult to recruit - especially if the definition of having a risk factor under 64 is loosely defined and most who want it can access the vaccine.

Prior leadership had set a foundation for universal COVID boosters in perpetuity. It's remarkable for new leadership to intervene and set a new path that requires the gathering of additional placebo RCT data in 50-64 yr olds for all new approvals, as well at additional placebo RCT data for any expansion of the indication.

FDA's reversal of the flu model track for all who are healthy under 65 yrs old for the COVID vaccines is no minor task.

What is your go to tv shows you watch to go to sleep? Mine is Forensic files, or anything to do with serial killers and true crime.

@christen_rexing Depends on your mood. This my go to “angst” song… m.youtube.com/watch?v=ZpUYjp…

I need the perfect song right now and I just can’t find it.

Some students in my clinical trials class this year were in a band (Walter & The Worms). I told them I would give them all extra credit on the final exam if they wrote and performed a clinical trial themed song. They nailed the assignment. m.youtube.com/watch?v=m-2ydN…