Proteinbase

Today we’re launching Proteinbase, a single hub for experimental protein design data. Over 1,000 novel proteins are already live, each with computational predictions, experimental validation, and the method used to design them. Everything comes from one lab under standardized protocols, which means the results are reproducible, comparable, and include negative data that usually never gets shared.

@adaptyvbio Open to students, academics, and industry. All you need is a laptop! Submit here → proteinbase.com/competitions/g…

Submissions are open for the GEM x @adaptyvbio RBX1 Binder Design Competition 🧬 We're partnering with the GEM Workshop at ICLR 2026 for a new protein design challenge. The target is RBX1, a 108-amino acid component of Cullin-RING E3 ubiquitin ligase complexes, which control degradation of roughly 20% of all cellular proteins. In many cancers, this protein is overexpressed and degrades important tumor suppressing proteins. Disrupting RBX1's function with a de novo designed binder could slow down cancer cell proliferation. But RBX1 is a tricky design problem. Half the protein is an intrinsically disordered N-terminus so it has limited use for structure-based design methods. The part you actually need to bind, the E2 recruitment surface on helix α2, sits within a RING domain with an usual fold that is shaped by three coordinated zinc ions. How it works: - Submit up to 100 ranked binder sequences (≤250 aa) with a design method description on Proteinbase till March 26 - An expert panel from the GEM workshop selects 300 designs based on novelty and originality - We test all 300 for expression and binding affinity in the @Adaptyv Bio lab - Experimental results will be released April 26 at ICRL 2026 in Rio de Janeiro and open-sourced on Proteinbase Prizes: $1,000 for the best binder, $100 for the runner-up, and co-authorship on the results paper.

Explore all de novo designs and data here: proteinbase.com/collections/ni…

Announcing the winners of the “De Novo” track of the Nipah Protein Design Competition! This track rewards completely novel design ideas. No starting scaffold, no antibody to optimize, no template to tweak: just the target structure and a blank canvas. Winners (by best binding strength) 🥇 Nick Boyd (Escalante) — KD: 1.4e-9 M 🥈 Johannes Klier (Schoeder lab)— KD: 1.2e-8 M 🥉 Brian Coventry (@UWproteindesign) — KD: 1.8e-8 M

We just added new protein card highlights to better show de novo designs on @proteinbase! We're checking all sequences against a bunch of databases via MMseqs2 search to ensure that the designs are not similar to already existing proteins.

The protein design competition results are out! Check out the full data here! proteinbase.com/collections/ni…

Also, last chance to make your predictions about the results on @ManifoldMarkets : manifold.markets/Proteinbase/in…

Nipah virus protein design competition update: The lab has been running nonstop for two weeks validating all 1,200 selected proteins. We’re now finalizing the last assays to make sure everything is properly validated, so we’re moving the results release to Wednesday, January 21st at 9am PST / 6pm CET. One thing we can say now: there are binders! 👀

Nipah virus protein design competition update: The lab has been running nonstop for two weeks validating all 1,200 selected proteins. We’re now finalizing the last assays to make sure everything is properly validated, so we’re moving the results release to Wednesday, January 21st at 9am PST / 6pm CET. One thing we can say now: there are binders! 👀

Nipah virus protein design competition update: The lab has been running nonstop for two weeks validating all 1,200 selected proteins. We’re now finalizing the last assays to make sure everything is properly validated, so we’re moving the results release to Wednesday, January 21st at 9am PST / 6pm CET. One thing we can say now: there are binders! 👀

We're launching a Protein Design Skills marketplace for Claude Code! We received a lot of questions about the protein design agent, so we're releasing the skills we used in the demo. The first batch includes skills for design generation, experimental testing, pipeline orchestration and more. The marketplace is open to community contributions too, so you can build and submit your own skills for others to use Install with /plugin marketplace add adaptyvbio/protein-design-skills and check out the full list here: proteinbase.com/protein-design…

Can Claude Code design proteins? We're just about to release our wet lab API + SDK so we made a quick demo to test how agents can interact with protein design models and submit the proteins to our lab for testing. This closes the loop between the computational design and the experiment validation We queued up a bunch of agent-designed proteins for wet lab validation, will release the results in a couple weeks on @proteinbase

The Protein Design Competition expert selection is live! We received so many impressive submissions that we doubled the number of handpicked sequences to 400. ➡️ Check out all the protein designs that will go into the lab for testing: proteinbase.com/competitions/a… Huge thanks to our experts for reviewing thousands of proteins in record time: @MartinPacesa, @btnaughton, @sokrypton, @BrianHie, @ferruz_noelia, @constance_frg, @BasileWicky, @anthonygitter, @CotetTudor, @simonduerr 💙