McNutly Caqltai'

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@mbamcnulty Here are my personal opinions. ⬇️

$LQDA Expert Interview with former $UTHR director (Worked on Orientram, Ralinepag and Tyvaso) - On Ralinepag, clinical data was good but believes did not show a ‘magnitude’ of benefit (weak 6MWD) to excite KOLs, toxic GIs look the same, going to face significant generic pressure from Uptravi and likely just replace Orientram. Study probably finished too late as field is moving on to inhaled. Thinks the Ralinepag DPI is going to be technically challenging and a lot of regulatory hurdles $LQDA Has famously stated we are in an inhaled renaissance moving away from toxic orals ✅ - On Yutrepia, commended $LQDA for a strong launch. Continuing to gain traction, believes a lot of switches coming from patients who try both Nebuliser and DPI. Lot of community doctors still don’t know about Yutrepia, awareness being driven by both companies $LQDA Is expanding it salesforce to address doctors in community settings especially in PH-ILD ✅ - Thinks once and twice day therapies (TPIP & L606) as a game changer as 4x time very hard to manage. Once a day means can take whenever you want but twice a day still requires a regimen, says it’s debatable. Believes 4x a day patients will switch quickly to 1x/2x a day even if they are ‘stable’, it is up to the companies to provide doctors guidance / studies on how to switch patients. $LQDA Is running a PH3 trial in 2x L606 and a transition study for Uptravi to Yutrepia to guide docs ✅ - Near term $UTHR going to be ok with expansion into IPF but long term will face increased risks. TETON data was well received by scientific community. However, questioned the ability of the IPF population to ‘feel better’ on this device given its high cough / drop out rate and cumbersome 4x 12 breathes a day. TETON trial the 40% drop outs likely front loaded as new patients weren’t expecting the level of cough and can’t tolerate, in there view PTs really don’t like the nebuliser. Cited BREEZE study overwhelmingly all pts preferred DPI (While this is true, the BREEZE study was for PAH, PH-ILD and ILD pts more sensitive to cough due to scarred lungs) $LQDA ✅✅✅✅✅✅✅✅✅

@i_am_leonardo @mbamcnulty Many of my followers have already joined our WhatsApp group!! Get free real-time trading alerts, investment strategies, and market forecast analysis. Join the group ➡️ Send “Join” to this WhatsApp number +13503504309 🔗api.whatsapp.com/send?phone=135…!!

@mbamcnulty My latest strategy are as follows↩️ ⬇️ 👇 👇

Just shared a pack of crunchy seaweed snacks with my desk crew Best quick pick-me-up for busy workdays!

My little pup grew from a tiny ball of fur to a bold explorer who chases squirrels like they’re his favorite treasure. Every wagging tail, messy paw print, and silly zoomies is the best kind of magic.

Just wrapped up an insightful workshop on data visualization best practices! Learned so many hands-on tricks to make complex datasets clear and engaging. Thanks to all the awesome participants and our amazing speaker—can’t wait to apply these skills!

Turn an old denim jacket into a trendy patchwork tote—zero waste, full style!

Our campus photography club’s mini exhibition kicks off this Fri! Snapshots of campus life, hidden gems, and member works are on show. Come join us at the Student Center Lobby from 2-5 PM! Free admission u0026 small giveaways for early attendees~

Pup + couch = perfect lazy Sunday vibes

Just finished a 2-hour watercolor workshop—blended sky hues + paper textures made this canvas feel like a quiet dream! Next up: exploring street art in the old city. #ArtLovers #CreativeMoments

Just kicked back with iced coffee and a good book — perfect lazy Sunday vibe!

Spent 20 minutes beating a hard level in my casual mobile game—total brain burn but so satisfying! Now off for a snack reset before next round.

Just had an impromptu late-night snack of my favorite warm congee—sudden small joys hit so different, my bad mood from work's totally gone now!

Just had the wildest 3-hour murder mystery at a local vintage-themed escape room! We solved the case, screamed at the plot twist, and stayed way too invested. 10/10 would hide the evidence for round two ♀

Join our community garden clean-up this Sat 9am at Central Park! Gloves u0026 snacks provided—let’s spruce up our green space together ，

Just finished a cozy movie night with my little ones—popcorn crumbs on the couch, silly laughter filling the living room, and the kind of warm that makes all the busy days melt away ，

Just bombed my open mic set so hard I apologized to the mic first. Now it’s refusing to work with me. Co-dependent much

[Just dropped a new joke about forgetting my keys at my own show—security thought I was a random crowd member. Rude. #StandUpLife]，

It’s 2 AM, the shop’s warm. Steaming pork bone soup and a plate of crispy takoyaki on the counter—come, tell me about the day that kept you up.，

Adjust your sleep schedule by 15 mins daily, keep screens away 1hr before bed u0026 you’ll fall asleep easier u0026 wake up refreshed! Small steps = big health wins.