Ravi R. Bhatt

📢 Full article ➡️ nature.com/articles/s4146… 🙏 Thanks to all co-authors, participants (UKB & ABCD), and funders.

Abnormalities in CC are genetically tied to ADHD and bipolar disorder. Smaller CC area shares allelic risk with ADHD, and thinner CC with bipolar disorder. Local effects on 17q21.31 link genu morphology to neuroticism and Parkinson’s via stress- and tau-related pathways.

📢New paper out! “The Genetic Architecture of the Human Corpus Callosum and its Subregions" investigates how genetic variation shapes the size & thickness of the corpus callosum (CC) - the brain’s major bridge between hemispheres. #neuroscience #genetics @NatureComms

We’ve mapped the genetic blueprint of the brain’s largest communication bridge using a new AI tool developed here by @njahanshad & co. Our publicly available tool reveals how genes shape this vital structure & may influence certain disorders. Learn more: bit.ly/47V28SJ

🚨Preprint alert!🚨"The Genetic Architecture of the Human Corpus Callosum and its Subregions" Meta-analysis of 46,685 European and replicated in 7,040 non-European ancestry individuals from the UK Biobank and ABCD studies. biorxiv.org/content/10.110…

💥#DDW2024 Research Forum! Stress-Resilience Impacts Psychological Wellbeing: Evidence from #BrainGut Microbiome Interactions 👤Desiree R. Delgadillo, PhD 👥@LabusJS @ravirbot @TienDongMD @AGuptaCNS et al ⏰Sunday, May 19, 8:48 am, 140 AB

🧠 Learn all about the largest brain imaging study of chronic pain to date from @njahanshad @ravirbot! The study pinpoints differences in gray matter in those with chronic pain compared to healthy individuals 👉 bit.ly/4aLXXYp

🎉 HUGE CONGRATS to our very own @ravirbot, who received a 2024 @USC PhD Achievement Award for his numerous accomplishments! This is the highest award from @uscprovost for PhD students USC-wide 🥇Congratulations to Ravi and his faculty advisor @njahanshad 👏👏

We thank the editorial board and reviewers for comments/critiques and the UK Biobank for providing an invaluable resource!

Mediation analyses revealed precuneus thickness mediated the relationship between chronic multisite pain and history of a suicide attempt, while the amygdala volume showed the strongest effect for a local pain site, and was specific to individuals with chronic abdominal pain.

📢🧠Now out in @BiologicalPsyc1 !🧠📢 Mapping Brain Structure Variability in Chronic Pain: The Role of Widespreadness and Pain Type and its Mediating Relationship with Suicide Attempt @njahanshad @USC_LoBeS #chronicpain bit.ly/3qBhEjR