realArnoldLab

We are looking for a new colleague :) Please, spread the word!

Finally out in print! Check out our study on multiparameter imaging to reveal cancer cell state-dependent crosstalk with stroma that determines patient outcome 👇

BTW, you now also find us here: @gastrulomicslab.bsky.social

Happy to share latest work from the Lab by lead author Chiara Schröder, out in DevCell: global enhancer remodeling giving competence for mesoderm/endoderm differentiation by co-workers EOMES and SWI/SNF. Transcription comes later! So, EOMES is not a TF, but a chromatin regulator!

I am very proud of Yasmine from the lab for winning a poster prize at the #GfE2024 organized by the German and Dutch societies for developmental biology for her work on Hes1 dynamics in the embryonic tail. Congratulations!

Please RT: Job opportunity! The Faculty of Medicine at the University of Freiburg, Germany, invites applications for a Full Professorship for Biochemistry and Molecular Biology. @UniFreiburg @Uniklinik_Fr med.uni-freiburg.de/en/administrat…

WRT the recent interest in TbxT, aka #Brachyury, & all kind of tails, nice historical perspective on this most iconic gene in the history of #DevBio shorturl.at/lEK57. Below, heroes of Brachyury (Fig.2 in ref ) + B. Herrmann, who cloned the gene &, of course, the T/+ mouse

Happy to share Tanja‘s new preprint: looking@transcription from quite a different angle: basal TFIID, IDRs and splicing.

@bxv_dev Hurray Geoffrey, great to see this being online! Can’t wait to read it!

TBX3 is essential to establish the posterior boundary of anterior genes and up-regulate posterior genes with HAND2 during onset of limb bud development dlvr.it/T2FCW2

"....Mouse embryos in diapause are sustained by using lipids as primary energy...." source nature.com/articles/s4155… by @bulutkarslioglu and colleagues. also another cool work by Aydan Bulut-Karslioglu and colleagues @NRivron @NiakanLab using this to control dev timing in 🕺🏃‍♀️human biorxiv.org/content/10.110…

We provide further evidence for the downregulation of NOGGIN by pSMAD, as predicted by our simulations, and detail the early antiphasic behavior of GDF5 and pSMAD that result from a self-organizing Turing system that drives joint initiation in developing digits of amniotes... 2/3

📢 Marc Timmers of Universitätsklinikum Freiburg will speak at our #DahlemColloquium! 📜 Basal transcription factor TFIID in neurodevelopment and neurodegeneration 📆 11. DEC, 11:00 AM (CET) 📍 MPIMG , Berlin 🔗 molgen.mpg.de/events/36185/3…

Very curious if anyone guessed this 😁 Our 2023 Method of the Year is methods for modeling development (aka embryoids)!!!! Some amazing things happening in this space enabling our understanding of the earliest stages of embryogenesis and beyond. Please enjoy the issue!

Two back-to-back manuscripts on metabolic control of germ layers using gastruloids/stembryos tinyurl.com/576pzzy2 by @KStapornwongkul in @LabTrivedi & @EbisuyaMiki and tinyurl.com/43e6x7su in @jvveenvliet! An exciting time for metabolism and in vitro models of development!

The modularity/robustness of #gastruloids to explore rltnshp between #metabolism/#CellFate; 3 #preprints @teamstembryo @jvveenvliet: shorturl.at/jptDE @KStapornwongkul @LabTrivedi shorturl.at/sxBFL earlier from @dd_chaitanya @BenSteventon2 shorturl.at/aozD4

Ever considered that the loss of your favorite epigenetic factor might impact gene expression in an allele-specific manner? Our new study shows allele-specific gene regulation by the chromatin regulator MSL2.nature.com/articles/s4158…

🚨 The lab of @AsifaAkhtar1 uncovered in @nature a mechanism that safeguards the biallelic expression of haploinsufficient genes. The epigenetic regulator MSL2 acts as an “anti-monoallelic” factor that maintains biallelic gene dosage. This discovery not only reveals a communication system between parental alleles but also points to potential therapeutic strategies for diseases associated with haploinsufficient genes. Congratulations to @sun_yidan, Meike Wiese & @raedhmadi 🥳 Press release: ie-freiburg.mpg.de/5808498/news_p… Paper: nature.com/articles/s4158…

@ksedzinski @UCPH_health @reNEW_Global Phantastic News!!! You are a Star!!!

Super happy that our#MechanoFate🐸 project received #ERCCoG funding! Huge thanks to my incredible team, friends, and colleagues for their invaluable help, as well as to the reviewers, and the panel. Exciting time ahead! @UCPH_health @UCPH_reNEW @reNEW_Global