René Geci

broadly applicable way to estimate key safety metrics (Cmax and AUC) reasonably well. Big thanks to Zeynep Edizcan, Stephan Schaller, and Lars Kuepfer for the excellent collaboration that made this work possible.

whether this is due to greater variability in the underlying PK data and clinical study protocols, or because dermal absorption is inherently more complex. Still, we conclude that despite the challenges in capturing absorption dynamics, the method offers a pragmatic and...

Our new preprint on high-throughput PBK modelling for #dermal exposure is now available 📄👇 “High-throughput PBK modelling for dermal exposure: a pragmatic approach to predict systemic pharmacokinetics” doi.org/10.1101/2025.1…

#DILI #InSilicoToxicology #NAMs #DrugSafety #PBK #BSEP #QSP #SystemsToxicology

Big thanks to Ahenk Zeynep Sayin, Lars Kuepfer, Stephan Schaller for the great teamwork and discussions that made this possible.

Still thinking that Drug-Induced Liver Injury (DILI) is hard to foresee? That LogP and Dose are good DILI predictors? Wondering why DILI often manifests idiosyncratically? Then you should read our new preprint! 📄👇

🤝 Interested in applying PSA to your own chemical portfolio? Let’s connect and chat! #OpenAccess #ExposureLed #NGRA #ChemicalSafety #NAMs #PBK #RiskAssessment #Toxicology #RegulatoryScience

Huge thanks to my co-authors Andrew Worth, Alicia Paini, Lars Kuepfer and Stephan Schaller, and to everyone who debated these ideas at the NAM Designathon workshop in Ispra 🇮🇹. Your insights were invaluable!

𝗛𝗼𝘁 𝗼𝗳𝗳 𝘁𝗵𝗲 𝗽𝗿𝗲𝘀𝘀: the second peer-reviewed paper of my PhD “Potential Systemic Availability (PSA) Classification of Chemicals for Safety Assessment” has just been published in Environment International and it’s fully open access. 🔗 doi.org/10.1016/j.envi…