The Rihel lab

As reigning Greater London Chess Club champion, Prof Rihel takes on 14 club players at once. Final score- 8 wins, 3 draws, and 3 losses against a tough group!

@anaclet_lab I think Estimation stats would do them wonders!

"It's not statistically significant but it's significantly better than all the other bars on the graph." This is a phrase I'll need to remember and borrow in the future.

@LuciaScience @sleepdiplomat @LunsfordAvery Ah, yeah, I found it from my mind grapes: There was even an Op-Ed on this idea in the New York Times in 2013: nytimes.com/2013/04/28/opi… But I never hear much about this now, and certainly I don't work with kids nor followed this area closely.

🔍 New research hints that behavioral sleep interventions, like CBTI, might benefit adolescents with ADHD. Could improving sleep quality also enhance ADHD symptoms? Dive into these intriguing findings and more in our discussion with @LunsfordAvery🛌💤 #SleepScience #ADHD

@LuciaScience @sleepdiplomat @LunsfordAvery Yes, I realize ASD/ADHD patients have a high rate of sleep problems, and there is some evidence that sleep interventions can ameliorate eg ASD symptoms. I was more asking on curiosity re: ideas in sleep dep/ADHD misdiagnosing, like this one: pubmed.ncbi.nlm.nih.gov/32976233/

@sleepdiplomat @LunsfordAvery Sorry if that’s in the video but as a rule I don’t watch videos here.

@sleepdiplomat @LunsfordAvery There were some papers years ago suggesting that kids with chronic sleep deprivation where getting diagnosed improperly as ADHD, and things like removing the tonsils in those cases fixed the apnea and sleep problems — and the ADHD like symptoms. What is the latest on that front?

Applications now open! Join the SWC PhD Programme 2025 🧠 World-class training in systems neuroscience 💰 Fully-funded 4-year programme 💂 Based in London with close links to @GatsbyUCL Learn more and apply by 11 Nov: sainsburywellcome.org/web/content/ph… #PhD #Neuroscience

Check out our preprint on new recombinant tools for reversibly ablating excitatory and inhibitory synapses. biorxiv.org/cgi/content/sh… Thanks to amazing first author @AidaBareghamyan and collaborators @RichKramerLab , Dave Chenoweth and Robert Campbell.

Excited to post a new preprint, work by @T___Kawashima, @zq_wei and collaborators: Voltage imaging reveals circuit computations in the raphe underlying serotonin-mediated motor vigor learning biorxiv.org/content/10.110…

Confusing stuff. Influx isn't efflux (clearance). Is it less gets in during waking or simply more on net gets out? Also, per intro, more Abeta is *secreted* during sleep deprivation, so its accumulation says little about clearance. biorxiv.org/content/10.110…

Very happy to have Boston Children's Hospital cover our recent Science paper on macrophages quality assuring stem cells by sensing ROS (dooming) or endogenous viral elements (grooming). This discusses our future plans. answers.childrenshospital.org/blood-cancers-…

I recently gave a talk on: Nonlinearity and network topology in multimodal circuits. Which you can watch here: youtube.com/watch?v=duzTIn…

Whoa!

@YanivElkouby Given how much wasted time for teams on both ends of live fish shipments lately, even if someone else is footing the cost, I am likely to only share lines via sperm shipment in the future, tbh. It is so easy!

@realRihellab Some are hesitant to perform IVF, but it’s a really simple protocol which requires only very simple common and cheap lab tools. We are happy to share our protocol. I encourage our #zebrafish community to move on to using this method for sharing lines so very easily. 🤟🏼🐟

Zebrafish peeps: I understand after many conversations at the Kyoto meeting that not everyone is aware of the Room Temperature zebrafish sperm paper. In Vitro Storage of Functional Sperm at Room Temperature in Zebrafish and Medaka | Zebrafish (liebertpub.com)

@ardemp I have to scroll past a lot of crap to find the science posts here now. Really degraded quality.

I know a lot of people are leaving this site. Are there any newbies still joining science-Twitter, or is this platform on its last legs? 🤔 I also post on LinkedIn occasionally, and even with ~50x fewer followers, I get similar engagement.

I loved the website 1 million checkboxes. And now I am even more pleased to see what the nerds were doing with the site. Incredible! eieio.games/essays/the-sec…

@MadS100tist It is a good point and we should keep track to see if anything obvious pops up.

@MadS100tist Good, cause that one shows there is no effect on methylation in the sperm when stored.... and when they go site by site in embryos at one stage, there are some differences in specific gene methylation, but is that very different than what you would get from 3 different dads?

@MadS100tist Changes made after the sperm itself is differentiated? Not epigenetic changes during spermatogenesis? any references?

@MadS100tist No, we haven't tested that yet. Would we expect it to have problems? Does sperm itself do a lot of epigenetics/provide anything other than DNA to the egg?