Reid Hoffman

Today, I launched Manas AI –– a full stack AI company setting out to shift drug discovery from a decade-long process to one that takes a few years; bringing life-saving treatments to patients faster than ever.

.@NotionHQ's Founder, @ivanhzhao: Stop trying to save costs when you're implementing AI. It's the easiest way to lose the race. More on how Ivan thinks about staying ahead of the AI curve:

Founder of the Innovative Genomics Institute, Jennifer Doudna sat down with @reidhoffman at #MoSSummit 2025 to discuss the breakthroughs CRISPR is sparking and how it could help address climate change. Watch: youtu.be/-zIvuSET310?si…

Don't overload your AGENTS dot md files. Keep them brief. GitHub's analysis of 2,500+ repos found what makes AGENTS dot md files work: - provide the agent a specific job or persona - exact commands to run - well-defined boundaries to follow - clear examples of good outputs

[1/5] Everyone is asking whether AI will replace cybersecurity products. But the real question is whether our current security architecture can even support what AI requires. To understand the effect of AI on cybersecurity, let’s roll back the clock for more than a decade.

Opinion: After Minneapolis, tech leaders’ deference to Donald Trump must end. 📝: @reidhoffman sfstandard.com/opinion/2026/0…

Every year, we co-host with @reidhoffman a hand-picked group of unicorn founders for an off-the-record, 24-hour gathering with no press. We call it The Grove. Over the years, participants have included Jensen Huang, Sam Altman, Satya Nadella, Patrick Collison, Tony Xu, Mira Murati, Eric Schmidt, and many others. This year’s edition, over the course of structured, off-the-record conversations, certain themes kept surfacing. Here are the field notes from those discussions. villageglobal.com/insights/field…

There are 18,000 human diseases, yet  14,000 of them don't have a single approved treatment. Dr. David Fajgenbaum on using AI to accelerate drug repurposing—finding where the medicines we already have could help patients who currently have no approved option:

10/ So, does AI save time? Well, yes. Does that time savings mean people do less work on average? Maybe not. One thing’s for certain: no one's getting their hours back. The only real question is what your organization (and your competitors) are converting them into.

9/ You don’t get to keep the AI amplification without consequences, because other players in your market also get the tool. Once everyone has the AI accelerant, it’ll be about how organizations intelligently deploy AI, and how they strategically reinvest the time savings that will separate the winners and the losers.

1/ The simple story about AI adoption within organizations is that it's all about saving time. That's not necessarily the whole story, though. Using AI a lot can make you more productive *and* leave people with more work to do:

The FBI cleared me. You on the other hand…

has anyone ever noticed how much this guy lies