Roberto Chiesa

Check out this article just published in @NatureComms Prion protein promotes copper toxicity in Wilson disease. Great teamwork with Roman Polishchuk @Tigem_Telethon @prionicus @MarioNegriIRCCS nature.com/articles/s4146…

Thrilled to share our latest collaborative work just published in Acta Neuropathologica Communications! @MarioNegriIRCCS @ZuckermanBrain actaneurocomms.biomedcentral.com/articles/10.11…

Our first paper peer-reviewed through @ReviewCommons now published in @PLOSONE

Grateful for the opportunity to talk about the #ProFFIle project (proffile-prion.eu) at the JPND Symposium in Bruxelles. @MarioNegriIRCCS @afiffitalia @f_prionicas @CICbioGUNE @NeuroBesta @MustafaogluLab

Intratecal delivery of allele-specific antisense oligonucleotide for an ultrarare neurological disorder nature.com/articles/s4159…

#bioGUNE_News | 🚴‍♂️ Fabio Mariuzzo biked over 2,000 km from Treviso to Bilbao to raise awareness for Fatal Familial Insomnia (#FFI), a rare prion disease 🌍 This morning, #CICbioGUNE welcomed him as we unite with Italy to boost research and hope! 🔗 ow.ly/YPlZ50TFzqV

Siamo arrivati a Bilbao!🤩🇪🇸 Si è conclusa l’ultima tappa di 2000km Per La Ricerca e Fabio ha varcato la soglia dei 2000km percorsi!🚴 Non possiamo fare altro che dire grazie a tutti coloro che, anche con un piccolo gesto, hanno deciso di contribuire a questo progetto ❤️🥰🤗

‼️TAPPA A MILANO‼️

Una biciclettata per l’insonnia fatale familiare Organizzata da @afiffitalia per far conoscere l’insonnia fatale familiare, una malattia genetica rarissima e fatale su cui Telethon sta lavorando per provare a cambiarne la storia naturale. telethon.it/storie-e-news/…

Insonnia Fatale: sabato 14 settembre la pedalata benefica "2000 km for Prion Research" dell’associazione Afiff farà tappa all’Istituto Mario Negri | Mario Negri marionegri.it/magazine/inson…

But of course this study has several limitations, which are thoroughly discussed by the authors

Somatic mutations may not play a major role in sporadic prion disease. Neuropathologically-directed profiling of PRNP somatic and germline variants in sporadic human prion disease biorxiv.org/content/10.110…

Peer reviewed @ReviewCommons version of the @GiadaLavigna et al. preprint now online. Trazodone, dibenzoylmethane and tauroursodeoxycholic acid do not prevent motor dysfunction and neurodegeneration in Marinesco-Sjögren syndrome mice biorxiv.org/content/10.110…

Our minireview on therapeutic targeting of the cellular prion protein is online. Congratulations to @antonio_masone, Chiara Zucchelli et al. journals.lww.com/nrronline/abst…

☀️ Avete già dato un'occhiata al nuovo progetto AFIFF "2000 km per la ricerca"? Se sì, ormai saprete già tutto. Se no, ve ne parliamo noi! Per donare, link qui --> To donate, here's the link --> ideaginger.it/progetti/2000-…

Congratulations to @GiadaLavigna and the team for their work evaluating partial PERK inhibitors and TUDCA in Marinesco-Sjögren syndrome mice!

Research focus: Mario Negri Institute "This year's Edinburgh Medal will be presented to the Mario Negri Research Institute in Italy for its open approach to sharing the results of its research." @TheLancet sciencedirect.com/science/articl…

The Mario Negri Institute was founded on the idea to that it would serve the public interest by sharing its research openly. This open approach has now been recognised through the Institute receiving the 2024 Edinburgh Medal. Peter Ranscombe reports. hubs.li/Q02r1w8C0

New fantastic research from the the Castilla lab @CICbioGUNE – a member of the ProFFIle (proffile-prion.eu/index.html) consortium, funded by @JPNDeurope – may contribute to develop improved diagnostic methods for Fatal Familial Insomnia and other prion diseases.