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Rosi
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Now online! Microbiome metabolism of dietary phytochemicals controls the anticancer activity of PI3K inhibitors dlvr.it/TL5t5S
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@vipintukur After being infected with SARS-CoV, my life was never the same. I struggled for over three years with chronic inflammation following recovery. The most significant impact was on my gastrointestinal tract, and I was later diagnosed with inflammatory bowel disease
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The relationship between the gut and #LongCOVID:
Researchers found that people with LongCOVID fatigue have damaged gut barriers & signs of immune activation.
Preexisting gastrointestinal symptoms before COVID infection predisposed people to developing LongCOVID fatigue. 1/

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Dr. Akiko Iwasaki, who has led work on the role of human endogenous retroviruses (HERVs) in chronic diseases i.e. lupus, is now investigating the role of HERVs in Long Covid. “We’re now collaborating to understand whether antibodies specific to Epstein Barr Virus can engage a pathological impact [in LC] when bound to this [HERV] cognate antigen.”
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Targeting metabolism to regulate immune responses in autoimmunity and cancer - a new review go.nature.com/2YuSfEE #immunometabolism

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5. In silico docking of 1.2 billion molecules, to the calcium-sensing receptor, to find new drugs
The top hit, '54149, was more potent than current drugs (like Cinacalcet), spared some side-effects, and may improve hyperparathyroidism treatment
science.org/doi/10.1126/sc…

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Kinase inhibition in autoimmunity and inflammation go.nature.com/3jcGMDR - a new review published today covering key kinase targets such as JAKs, IRAK4, RIPKs, BTK, SYK and TPL2

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This Review in the February issue discusses progress with enhancing the activity of endogenous regulatory T cells or delivering them as cell-based therapies for allergy, autoimmunity and cancer
nature.com/articles/s4157…
rdcu.be/d80zV

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#EveryCellIsAnImmuneCell! Rakoff-Nahoum & Chatila labs @BostonChildrens @harvardmed show @Nature that in food #allergy intestinal goblet cells produce RELMb which depletes #microbiota producing indole metabolites necessary to activate AHR & drive Tregs! nature.com/articles/s4158…
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@RositaHandayani @RositaHandayani Hello Kak Rosita, meralat informasi sblmn ya. Utk perihal tsb mohon dpt dijelaskan kronologisnya via DM utk menjaga kerahasiaan data.
Ditunggu ya, trims -Aren
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