Niels J. Rupp, MD

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Niels J. Rupp, MD

Niels J. Rupp, MD

@rupp_md

Head & Neck, Oral & Maxillofacial and Genitourinary pathologist.

Zurich, Switzerland Katılım Şubat 2021
209 Takip Edilen422 Takipçiler
Niels J. Rupp, MD
Niels J. Rupp, MD@rupp_md·
@WeinrebIlan @ENTpathology Good point. I dont know if there is a clear cutoff regarding frequency (anyone?). From my understanding non-canonical means exception from the rule or typical findings. So, I have seen a few („recurrent“) identical „non-canonical“ (other-than-V600E) BRAF mutations.
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Niels J. Rupp, MD retweetledi
IAOP
IAOP@IAOPath·
The International Collaboration on Cancer Reporting (ICCR) has published the second edition of Head and Neck dataset. @iaopath is one of the contributors to the dataset! Please visit the ICCR website to access free datasets: iccr-cancer.org/datasets/publi… #oralpath #ENTPath #ICCR
IAOP tweet media
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Niels J. Rupp, MD
Niels J. Rupp, MD@rupp_md·
Many thanks to Tina Mauthe and all those involved for this close and excellent collaboration to study this rare tumor disease.
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Niels J. Rupp, MD
Niels J. Rupp, MD@rupp_md·
Our cohort showed a high prevalence of MYB::NFIB gene fusion, which can also help to confirm diagnosis in cases with unusual morphology (such as the so-called metatypical AdCC).
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Niels J. Rupp, MD
Niels J. Rupp, MD@rupp_md·
In addition, eight of nine cases, invisible on PET, showed IHC-ERG+, and an underlying TMPRSS2::ERG gene fusion by next generation sequencing.
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Niels J. Rupp, MD
Niels J. Rupp, MD@rupp_md·
In concordance with our previous work, that IHC-PSMA negative areas are associated with decreased visibility on 68Ga-PSMA-11 PET scans, the IHC-ERG+ cases showed decreased visibility on corresponding PET scans.
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Niels J. Rupp, MD
Niels J. Rupp, MD@rupp_md·
In addition, eight of nine cases, invisible on PET, showed IHC-ERG+, and an underlying TMPRSS2::ERG gene fusion by next generation sequencing.
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Niels J. Rupp, MD
Niels J. Rupp, MD@rupp_md·
In our cohorts we identified a frequent molecular subgroup of primary prostate cancer, ERG+ by immunohistochemistry (IHC), which does show an increased heterogeneity of IHC-PSMA expression by IHC, and above all more IHC-PSMA negative areas.
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Niels J. Rupp, MD
Niels J. Rupp, MD@rupp_md·
@MirunaPopescu13 @DrGeeONE With this kind of morphology, although admittely rare, one should also consider ALK rearranged RCC, as they may show this metanephric adenoma like spectrum.
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Niels J. Rupp, MD
Niels J. Rupp, MD@rupp_md·
@Ruthra3596 Well, with regard to the purely biphasic differentiation thats also a good differential diagnosis. They recurrently harbor ctnnb1 mutations, usually show more stroma and are mainly observed in the major salivary glands.
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Ruthra
Ruthra@Ruthra3596·
@rupp_md The very first think that striked my mind was basal cell adenoma😂
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Niels J. Rupp, MD
Niels J. Rupp, MD@rupp_md·
One can discuss morphological and molecular overlap with highly unusual epithelial-myoepithelial carcinoma of the sinonasal tract, but there are some arguments to favor a spectrum of LGSNAC. More to come soon!
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Keşfet

@WeinrebIlan @ENTpathology @iaopath @MirunaPopescu13 @DrGeeONE @Ruthra3596 @Histo_Journal @elonmusk