Ryan Boe

43 posts

Ryan Boe

@ryanboe0

@Penn MD/PhD student in the lab of @arjunrajlab

Philadelphia, PA Katılım Ocak 2021

105 Takip Edilen90 Takipçiler

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Ryan Boe@ryanboe0·29 Kas

So excited that our manuscript (cell.com/cell-systems/f…) is out today in @CellSystemsCP! Thank you to the reviewers and editorial team for improving the work and big shout out to my fellow co-authors @VinayA116 @SchuhLea @arjunrajlab. Original tweetorial below!

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Guillaume Harmange@GHarmange·7 Kas

My thesis work on drug resistance in melanoma is now published in @NatureComms! nature.com/articles/s4146…

Guillaume Harmange@GHarmange

I am excited to present my PhD work where I show that it is possible to manipulate the gene expression state of cancer cells to make them more susceptible to drug. 1/n biorxiv.org/content/10.110…

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Sam Reffsin@SamReffsin·11 Tem

Very excited to share our work on identifying novel transcriptional states that drive variability in SARS-CoV-2 infection at the single cell level! biorxiv.org/content/10.110…

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Raúl Reyes Hueros@HuerosRaul·6 Haz

I'm excited to share our new @biorxivpreprint! We found that individual epithelial cells grow to dramatically different sizes within a fixed time. This variability in proliferative capacity is governed by both cell-intrinsic and cell-extrinsic factors. 1/n biorxiv.org/content/10.110…

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Harry McNamara@h4rrymcnamara·5 Haz

hello world! new results (with @toettch): tinyurl.com/3595banh Stem cells can self-organize morphogenesis in vitro w/o spatial patterning cues. But how? We programmed cells to record their signaling histories to map symmetry breaking during gastruloid morphogenesis (1/n)

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Nature Computational Science@NatComputSci·24 Nis

In a recent Review, @yogeshgoyallab and colleagues discuss how computational tools can be leveraged to gain insights into the origins and nature of non-genetic heterogeneity in cancer. nature.com/articles/s4358… 👉rdcu.be/daCJb

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Jay Gertz@GertzLab·16 Mar

The latest @GertzLab preprint was just posted. It was a great group effort led by @tweeterginley with help from @xyzxiaoyang lab and John Lis’ lab. In this study, we explored how regulatory elements influence gene expression timing and noise in response to estrogen 1/

bioRxiv Genomics@biorxiv_genomic

Cis-regulatory control of transcriptional timing and noise in response to estrogen biorxiv.org/cgi/content/sh… #biorxiv_genomic

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Connie Jiang@cojiberries·13 Nis

Very grateful for the kind reception/sharing of this document over the past few years! Since graduating from the lab I've been updating a personal edit which I'm excited to share~ docs.google.com/document/d/1ps…

Connie Jiang@cojiberries

Took some time this week to write up some basic guidelines about how to use one of my fave #sciart tools @Illustrator to create scientific figures and blogged about it here: rajlaboratory.blogspot.com/2019/08/i-adob… (link to guide publicly available at end of blog post)

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Ryan Boe@ryanboe0·10 Nis

@yogeshgoyallab @CancerRF Congrats! Had the pleasure to work with Yogesh when he was a postdoc and can vouch for him as an incredible mentor and scientist!

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Sara Rouhanifard@SRouhanifard·7 Nis

Preprint alert! Multicellular, IVT-derived, unmodified human transcriptome for nanopore direct RNA analysis. biorxiv.org/content/10.110…

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Prof. Nikolai Slavov@slavov_n·28 Mar

@CellGenomics Here is the answer (ClonoCluster) developed by @arjunrajlab, @yogeshgoyallab and colleagues. 2/2 cell.com/cell-genomics/…

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Dylan Schaff@DylanLSchaff·28 Mar

Very excited to share the @biorxivpreprint of my first, first-author paper of grad school with my amazing former undergrad and co-first author Aria Fasse! biorxiv.org/content/10.110…

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Arjun Raj@arjunrajlab·14 Şub

Question: what are people’s favorite *curated* gene sets for expression differences specific to cancer. Like, notch signaling, but more specifically the aberrant expression levels of notch and associated factors in cancer.

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Naveen Jain@uffdaALLberries·13 Şub

1/ Excited (and relieved) to share our new work with @arjunrajlab on identifying intrinsic factors marking rare somatic cells “primed” to become pluripotent stem cells before reprogramming even starts @CAMBUpenn, @PennGenetics, @PennEpiInst, @pennbioeng. biorxiv.org/content/10.110…

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Sydney Shaffer@sydshaffer·2 Şub

Excited to share our latest preprint led by Rodrigo Gier!!🥳🥳 with @HuerosRaul and amazing collaborators @NancyZh60672287 @DrGaryFalk @LabMuir @tkarakasheva Lineage tracing with scRNA-seq to track the origins of metaplasia and its evolution to cancer. biorxiv.org/content/10.110…

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Ryan Boe@ryanboe0·30 Kas

@CellSystemsCP @VinayA116 @SchuhLea @arjunrajlab twitter.com/ryanboe0/statu…

Ryan Boe@ryanboe0

Excited to present our work with @arjunrajlab which puts forth a theoretical model combining correlated allelic expression and noise transmission, and outlines an important design principle for the signal transmission properties of genetic networks biorxiv.org/content/10.110… 1/7

QME

Ryan Boe@ryanboe0·29 Kas

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Nature Methods@naturemethods·24 Eki

ClampFISH 2.0 enables highly specific multiplexed signal amplification in RNA FISH. @arjunrajlab @IanDardani @BenEmert @yogeshgoyallab @cojiberries @SRouhanifard @FaneMitchell @gretchen_alicea @HerlynLab @AshaniTW nature.com/articles/s4159…

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lea.schuh@SchuhLea·19 Eki

Our paper „Altered expression response upon repeated gene repression in single yeast cells“ is now out @PLOSCompBiol 📄🎉 Huge thanks to Igor Kukhtevich, Poonam Bheda, Melanie Schulz, Maria Bordukova, @robert_ife, and @MarrCarsten! Take a look here 👀 journals.plos.org/ploscompbiol/a…

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Edda Schulz@EddaGSchulz·6 Eki

Can we quantitatively tune endogenous gene expression to understand dose-dependent processes in cells? @GemmaNoviello has developed a 🛠️ to do that - #CasTuner 📻 - with the help of @RutgerGjaltema 👉 biorxiv.org/content/10.110… See Gemma‘s tweetorial 👇

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Ruxandra Teslo 🧬@RuxandraTeslo·8 Eyl

“How should we classify cell types?” is becoming a pervasive question as large scRNAseq datasets are accumulating. The next paper (@arjunrajlab) in non genetic heritability series explores how cell clustering changes when scRNAseq & lineage info are given different weights.

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Keşfet

@NatureComms @biorxivpreprint @toettch @GertzLab @tweeterginley @xyzxiaoyang @CancerRF @CellGenomics