Sam Gamble

Very excited to see our work out now in Cancer Cell! And congrats to Evie Fitzsimons for spearheading this effort 🧬 @kevlitchfield @JL_Reading

Huge congratulations to Evie and my fellow co-authors on our recent work exploring intratumoral B cells, just published in @Cancer_Cell. Many thanks to @kevlitchfield & @JL_Reading for their hard work and support throughout.

Fantastic paper. One of the clearest articulations that current ML methods *can* solve the TCR specificity problem, if given sufficient data. I remain very surprised at the redundancy of individual positions in epitope sequence without altering T cell activation.

Does cancer #evolution & intra-tumour heterogeneity predict long-term relapse? We tested the evolutionary paradigm in prostate cancer clinical trials with long follow-up, combining genomics with digital histopathology: nature.com/articles/s4301…

Another proud PI moment from June, the lab’s spatial biology guru @andreiinsilico describes the cellular ecosystems regulating T cell surveillance in premalignant lesions during pulmonary carcinogenesis at the @uclcancer conference; all from a blank canvas inside 18 months 👏

@JL_Reading @Harvard @CRUKresearch @uclcancer Thanks James! Hugely grateful to have been given the opportunity.

Our superstar PhD student @sam__gamble elegantly describing the mechanisms of immune regulation that foster lung cancer development at the roadblock first annual cancer prevention conference @Harvard @CRUKresearch #prevconv24 @uclcancer

Very happy to share our latest pre-print studying T cell dynamics in multiple myeloma disease evolution 🧵1/10. medrxiv.org/content/10.110…