Sam Brill-Weil

Excited to share my first, first-author paper from back during my time as a postbac with @KhaliqLab! Here, we examine how two presynaptic receptors interact to shape DA axon physiology and excitability. 1/n👇 biorxiv.org/content/10.110…

Happy to share the first work from my PhD. 🔬 We show that GPCR-based norepinephrine and dopamine sensors can display crosstalk in acute brain slices and in vivo.⚡️ We hope this study will be helpful for those using these sensors and for interpreting results. 🐁

Innervation density governs crosstalk of GPCR-based norepinephrine and dopamine sensors biorxiv.org/cgi/content/sh… #biorxiv_neursci

Exciting work from the lab on unique DA subpopulation! SN pars lateralis DAN firing differs from SNc in super interesting ways. We find robust auditory CTX input and test in threat behavior. Congrats to Lorenzo Sansalone (@newrochemist), @cellularscale @e_twedell, Sherry Zhang!

@newrochemist @KhaliqLab Congrats Lorenzo!!

@StephRudolphLab @KhaliqLab Thank you!!

Excited to share my first, first-author paper from back during my time as a postbac with @KhaliqLab! Here, we examine how two presynaptic receptors interact to shape DA axon physiology and excitability. 1/n👇 biorxiv.org/content/10.110…

Check out the preprint for the rest of our findings – feedback is welcome! Lastly, a huge thank you to all the co-authors, and especially @KhaliqLab and @XOanAxon who have been and continue to be incredible mentors to learn from. 6/6

Along the way, we noticed big differences in the effects of gabazine and picrotoxin, two common GABAAR antagonists. Turns out, picrotoxin strongly inhibits nAChRs on DA axons! We characterized this off-target inhibition in the hopes that it will be useful to the community. 5/n

@XOanAxon @UMich_MCDB Congrats Paul!!

I’d like to share that this fall I will join @UMich_MCDB as an Asst. Prof! It’s been a long scientific journey, and I am very excited about this big next step in my career. I really couldn’t have found a better department to join! Look here for future Kramer Lab info! 🧠!🔬!🫵?

@anna_lipkin @KhaliqLab @NINDSnews Congrats Anna!

Hard to believe my time in grad school is finally done! I'm so thankful to everyone who helped me along the way. And I'm thrilled for the next step, a postdoc fellowship with @KhaliqLab at @NINDSnews! To the AIS and beyond!

Thank you to @BJunDing and @albarran_neuro for writing such a great and super fun preview of our article! “Voltage is Truth” YES! W’axon, wax off: Striatal cholinergic synapses instruct dopamine axon activity cell.com/neuron/fulltex…

@SilberbergGilad @KhaliqLab @PiN_Harvard Thanks so much, Gilad! I appreciate it!

@sambrillweil @KhaliqLab @PiN_Harvard Congrats for a great paper and good luck with the next adventures!

There's no better way to wrap up my time with @KhaliqLab than to see this out in its final form!! The last two years have been an incredible experience and I'm sad to leave such an amazing environment. But for now, on to new adventures at @PiN_Harvard! cell.com/neuron/fulltex…

@DrRDShep @KhaliqLab @PiN_Harvard Thanks Ryan!!

@sambrillweil @KhaliqLab @PiN_Harvard Congrats!! Looking forward to seeing some of your future ephys work

@mottcallie @KhaliqLab @PiN_Harvard Thanks, Matt! Can’t wait!!!

Incredibly proud to have contributed to this project!! Of course, huge thank you to @XOanAxon and @KhaliqLab for helping me learn these difficult and beautiful recordings when I first joined the lab. DAxons truly never cease to amaze…

Well I guess our paper has spread faster than I expected for a Sunday! Here is a short tweetorial for our recent @KhaliqLab study just posted to BioRXiv. TLDR: We see synaptic-like ACh transmission onto dopaminergic axons in the striatum. biorxiv.org/content/10.110…