Justin Sanchez

So far med school has taught me that I owe everything to these 2, and slightly more to my mom because of mitochondrial DNA

Does Alzheimer’s disease pathology spread through the brain consistently across the population? We delve into this in our paper “Four distinct trajectories of tau deposition identified in Alzheimer’s disease”, now online at Nature Medicine. #Sec23" target="_blank" rel="nofollow noopener">nature.com/articles/s4159… Thread below 1/

@ytquiroz @harvardmed @MGH_RI @MGHmapp @HarvardAging Thanks Yakeel!! Very grateful for your amazing mentorship 🙏

NEW: we show that the protective effect of #APOE-ε2 against developing clinical #Alzheimer's is primarily linked to #resistance against #Aβ rather than #tau pathology. Congratz @gesalbla and Michel Grothe! bit.ly/39GUGfZ w/@_michael_scholl @AlexisMoscoso9 @JuandoGispert

“Metadata” is one of those things that sounds more awesome than it is

@victorpsanchez @MGHmapp Thanks friend!!

Big shoutout to @sanchez_js1, a brilliant early-career neuroscientist and would-be doctor (perhaps a psychiatrist?) disentangling the mysteries of #Alzheimers with PET imaging at @MGHmapp! In the last few days, he has published two important papers moving the field forward.

Practical advise on the use of white matter as a reference region in tau PET, another gem by our very own @AlexisMoscoso9 , out now in EJNMMI. #alzheimers #tau #pet link.springer.com/article/10.100…

Our paper "APOE interacts with tau PET to influence memory independently of amyloid PET in older adults without dementia" is out now in @alzdemjournals! Check it out here (alz-journals.onlinelibrary.wiley.com/doi/abs/10.100…), or see below for a graphical summary. 1/2

🎉🎉Also this week, my 2nd first-author paper, on longitudinal aβ and tau PET in the Colombian kindred with autosomal dominant #Alzheimers, came out in @AlzheimersRes - check it out! Big shout-outs to @ytquiroz @MGHmapp and all coauthors!! alzres.biomedcentral.com/articles/10.11…

@DesmondWarren10 @CorriveauNick @HarvardAging @FraminghamStudy @MGHmapp @ADRCMass Thanks, Desmond!!

🎉Thrilled to have published my first first-author paper, a deep dive into the site of origin and initial spread of MTL tau in #Alzheimers using PET An amazing collaboration b/w @HarvardAging @FraminghamStudy @MGHmapp @ADRCMass stm.sciencemag.org/content/13/577…

@CorriveauNick Thanks Nick!!

@Vee_0111 Thank you!!

@sanchez_js1 Congratulations! Awesome!

Huge thank-you's and congrats to all my coauthors and mentors, including @DrHeidiJacobs @Aaron_P_Schultz @Frutiloopz @AODonnell_5 @ytquiroz @sudha_md, all the folks at @MGHNeurology @MGHGordon @MGHMartinos, Keith, and many others !!

RC tau was the strongest baseline predictor of subsequent neocortical (inf temp, IT) tau increase, outperforming both aβ (PiB) and IT tau

@relajoie Thanks Renaud!!

Thanks Yakeel!! Very excited to share these findings from COLBOS. Big thank-yous and congrats to all my co-authors and mentors

Hello Twitter! Many trusted friends have told me this is place to be for keeping up with the latest in neuroimaging / AD research / gifs / memes / etc. So here I am 😎