Sam Scherer

New PhD student after discussing potential projects/ideas with supervisor #PhD #chemtwitter #phdlife #research #researchers @PhDVoice #phdmemes

Why would I calculate something by hand when I can simply take 4 times as long to code a solution?

Scientists will claim to be logical and rational people, but then warn you not to move the small plush toy in the lab or the equipment will get upset and stop working.

Did vaccination drive the evolution of variant (Alpha, Beta, etc...) SARS-CoV-2 viruses? This is a legitimate scientific question, but after looking into it I don't believe this to be the case. 1/19

The Kay Lab develops D-peptide inhibitors against infectious diseases. Learn more about how they do this in this excellent stop-motion video and at their website kay.biochem.utah.edu youtu.be/MjTYTOqgkzQ

Welcome Sam!

There are so many great student projects being discussed during the #DURSS2020 Join the conversation! #DUUGResearch - undergrad students #DUGradResearch - graduate students

@SamirRezgui_ Excitingly, these drugs have all undergone a full drug development process, showing they are highly bioavailable, and are known to freely cross, or are actively transported through, cell membranes. This reduces the chance of a false negative/positive going from in vitro to vivo.

@SamirRezgui_ Thanks for the response, Samir! The main hurdle remaining before a clinical trial is that of mouse GBM patient derived xenograft (PDX) models. This in vivo system should give us more insight on how carfilzomib can work on tumors in the body. (1/2)

Join me tomorrow at the DU Virtual Research Symposium to learn about my work treating glioblastoma with FDA-approved drugs. #DURSS2020 #DUUGResearch Find a version of my presentation here: prezi.com/p/ow6d9z0kfwqt…

@TeddyWroblewski Thank you for the question, Teddy. Getting these already FDA-approved drugs into the clinic is easier than starting from square one with unapproved research compounds. A series of PDX models would be necessary before beginning clinical trials for carfilzomib with GBM.

@scherer_sam Interesting work Sam, well done. These results clearly demonstrate that compounds DO exist which can reduce GBM viability, this is exciting news. Given the gravity of these findings, what do you believe are the next steps to get these efficacious compounds into the clinic?

@ryankeenan1021 @US_FDA Ryan, I agree the results are promising, however significant work is necessary to validate these findings before exploring carfilzomib for GBM treatment in humans. Future directions will most immediately include PDX mouse models. Thanks for your interest!

@scherer_sam Exciting results with your study! Using the words of Marie Curie, "I was taught the way of progress is neither swift nor easy", hopefully, we can utilize your hard work to increase the 10-year survival rate of glioblastoma by getting the @US_FDA to approve carfilzomib #DURSS2020

@SamirRezgui_ Interesting! Thanks for the response.

@scherer_sam (1/2) Hi Sam, thanks for the great question! A 2015 paper revealed these two ligand modifications increased the catalyst initiation rate on Hoveyda-Grubbs catalysts. We believe it is this step that dictates how fast our probes turn-on,

With some funding from DU URC I was able to some do fun and cool work over the past year! Check out my project “Synthesis of Fluorescent Compounds to Detect Ethylene" prezi.com/view/sP1eWW7dr… #DURSS2020 #DUUGResearch

I have been fortunate enough to be part of a lab aimed to find novel treatments for brain tumors. Our work has enabled the screening of many tumors & could not have been done without my stellar colleagues, @scherer_sam, & @willforeman_. See Sam's work on GBM's, excellent work!

I was very fortunate to present my work at the NASBS Conference this spring supported by the @UofDenver Student Scholar Travel Fund. Take a look at my work on the inhibition of PDGFR as a viable treatment option for meningiomas: prezi.com/view/60mSPlKtc… #DURSS2020 #DUUGResearch

Join us tomorrow for the DU research showcase! I’m also giving a keynote presentation at 1, be sure to tune in! du.edu/research/showc… #DURSS2020