Marija Krasiļņikova

Pleased 2 share our new article: single-molecule replication mapping in Leishmania using DNAscent. We show widespread stochastic origin firing and insights into genome variability. cell.com/cell-reports/f… Big thanks to Mike Boemo

32 T2T!!! Happy to share our preprint showing the molecular karyotype of #Trypanosomacruzi @GonzaloGreif @fdiazviraque #MariaLChiribao @CarlosSanz22 @PacBio HiFi biorxiv.org/content/10.110…

More recent work from the McCulloch lab! Check out Jeziel's @jezielbqi recent paper on R-loops, DNA replication and genomic stability in Leishmania major nature.com/articles/s4146… in @NatureComms @McCulloch_Group @MarquesCata @rmc9z @emmabriggs6

@jezielbqi @McCulloch_Group @emmabriggs6 @MarquesCata Woop woop!

Excited to share our latest work on R-loops and RNAse H1, exploring their roles in genome replication timing and stability. It’s now published! nature.com/articles/s4146… @McCulloch_Group @emmabriggs6 @scotomorph @MarquesCata

We're pleased to share a new paper @UofGSii @WCIPGLASGOW led by @scotomorph @MarquesCata where we show that T. brucei DNA replication dynamics reflect structural and functional compartmentalisation of the genome. Well done Marija! doi.org/10.1038/s41467…

@JoanaRCF @rmc9z @MarquesCata @emmabriggs6 Thank you 🖤

@scotomorph @rmc9z @MarquesCata @emmabriggs6 Congratulations!!!

DNA replication beyond the cores of megabase chromosomes of T. brucei -- some of my PhD work is FINALLY out! doi.org/10.1038/s41467… thanks to @rmc9z @MarquesCata @emmabriggs6 Dario, Kathryn, Graham and Craig! 🥳

Drs Stephen Larcombe @jane_munday & @rmc9z highlight @MonicaMugnier & colleagues’ @Nature article on tissue spaces as #reservoirs of #AntigenicDiversity for #Trypanosoma #brucei. @SBSatEd @WCIPGLASGOW @UofGSii @JohnsHopkinsMMI @JohnsHopkinsSPH #Trypanosome cell.com/trends/parasit…

@jezielbqi @McCulloch_Group @gabriellamak @MarquesCata @WCIPGLASGOW Spoiler alert in the title, heh

Fancy a sneak peek into Leishmania’s unusual DNA replication programming? At @McCulloch_Group we used D-Nascent to map origins & forks at the single-molecule level, revealing novel, abundant replication initiation events across its plastic genome. See links below👇

Are you interested in genome maintenance, organisation and replication? We have a BBSRC-funded PhD position to use multi ‘omics’ approaches to tackle this problem! ⁦@McCulloch_Group⁩ ⁦@UniOfYork⁩ ⁦@YBRI_UoY⁩ findaphd.com/phds/project/m…

How does Leishmania major replicate its genome? A sneaky Sneak Peek at a recent manuscript from our lab @McCulloch_Group (led by Jeziel @jezielbqi) currently under review: dx.doi.org/10.2139/ssrn.5…

@OlympiaMHardy Woop woop!

Immensely proud to tell you all my first paper of my PhD is out in Nature Medicine now! We wanted to know if the immune response to COVID-19 was distinct in an African cohort (spoiler alert: our data suggest it is!) Give it a read! nature.com/articles/s4159…

Very happy to share new work @UofGSii @WCIPGLASGOW led by @jezielbqi describing very abundant, previously undetected DNA replication activity in Leshmania using DNAscent, a technique developed by @CNieduszynski Great work, Jeziel. shorturl.at/G7uRm

Funded PhD available with us, @martllewellyn and James Cotton @UofGSii @UofGSBOHVM @WCIPGLASGOW to study genome replication and (in)stability across diverse kinetoplastids. Applications (via FindaPhD) taken from Nov 1st - Jan 12th. Enquiries welcome. tinyurl.com/mfz4yh3k

Is 915 jupyter notebook cells an indication that it's time to move on to analysing some other data?

Our new study led by @scotomorph @MarquesCata We used Nanopore sequencing to map DNA replication across the whole T. brucei genome, revealing partitioning that drives instability for immune evasion @KathrynCrouch81 @emmabriggs6 biorxiv.org/content/10.110…

We’re pleased to share a new study led by @jezielbqi describing how R-loops and RNase H1 dictate chromosome size-dependent DNA replication timing and genome stability in Leishmania @emmabriggs6 @scotomorph @MarquesCata biorxiv.org/content/10.110…

And this one's doing cartwheels

This trypanosome chromosome looks like it's having a great time, no?