SeqDesign

can peptides help your muscles grow bigger? GLP-1's are incredible tools to help lose weight, but how much of that is muscle vs fat? Can we use AI to design new and better muscle growth peptides? Let's dive in:

let's design a peptide to inhibit MYC-MAX with AI 🧵 MYC is the most-cited oncogene in human cancer and is deregulated in ~70% of tumors Forty years of small-molecule chemistry has produced exactly zero approved direct MYC inhibitors

Built a tool for myself to easily trim/view/search/download/renumber protein structures for binder design tasks (even on the phone!) wanted to share in case its helpful to anyone else seq.design

I just got laid off this morning from Myriad Genetics Looking for new opportunities, RT’s appreciated, DM’s open My experience: Protein design + engineering NGS + Bioinformatics + some software dev Data Science + Analytics Synbio + Cancer Genetics

Evolving better binders with continuous hypermutation Really cool paper uses OrthoRep to evolve stronger de novo binders Cool insights: -most beneficial muts were outside of the interface -with strong selection, muts were additive -with weak selection, more neutral muts