


Stephanie G Worrell, MD FACS
734 posts

@sgworrell
Associate Professor and Section Chief Thoracic Surgery University of Arizona










Matterhorn falters on OS EFS HR 0.71 🧪 NEJM MATTERHORN Trial — Periop Durvalumab + FLOT in Resectable Gastric/GEJ Cancer n=948 | Global Phase 3 | FLOT backbone 🎯 Primary Endpoint: Event-Free Survival (EFS) 📊 2-yr EFS: 67.4% vs 58.5% 🕒 Median EFS: NR vs 32.8 mo 🧮 HR 0.71 (95% CI: 0.58–0.86), p < 0.001 🧬 Pathologic CR: 🔹 19.2% vs 7.2% 🔹 RR 2.69 (95% CI: 1.86–3.90) ⚰️ Overall Survival (OS) 📆 24-mo OS: 75.7% vs 70.4% 🕒 Median OS: NR vs 32.8 mo 🧮 HR (0–12m): 0.99 → ❌ no early OS benefit 🧮 HR (≥12m): 0.67 → ✅ delayed IO effect 📉 OS p = 0.03 > alpha (0.0001) → Not significant yet 🛡 Safety 🧾 G3–4 AEs: ~71% both arms 💥 irAEs: 23.2% (vs 7.2%) 🕒 Delayed surgery: ~10% both arms ⚖️ Critique ❗ EFS + pCR ✔️ ❗ OS ✖️ not yet significant ⚠️ No clear biomarker enrichment (PD-L1 or MSI-H) 🛠 Surgical variability not controlled 🧪 Awaiting final OS for SoC impact 🧠 Verdict: Encouraging but not SoC (yet). #NEJM #ASCO25 #GastricCancer #Immunotherapy #Durvalumab #OncoTwitter @dr_yakupergun @GIMedOnc @GIcancerDoc @UGrewalMD @OncoAlert


























Join us for the AATS/WTS Reception at the 105th AATS Annual Meeting in Seattle! Connect with colleagues and celebrate our community on Friday, May 2, from 5:30–7:30 PM in Theater 3, Exhibit Hall. This event is open to all WTS supporters and members; no registration is required.

