Sukhyun Lee

Pd-Catalyzed Counter-Steric Site- and Chemoselective Glycosylation: Total Synthesis of Fridamycin A and Himalomycin B | Journal of the American Chemical Society @postech2020 pubs.acs.org/doi/10.1021/ja…

Copper-Catalyzed Regio-, Diastereo-, and Enantioselective Allylic Alkylation with 1,1-Diborylalkanes | Journal of the American Chemical Society @TotalSyntheses #Cu #Catalysis #Regio #DiastereoSelective #Enantioselective #Allylic #Alkylation #DiborylAlkanes pubs.acs.org/doi/10.1021/ja…

Excited to share our latest work on chemical permutation, now published in @Nature! Using photochemical conditions, we've developed a method to selectively and predictably transform the structures of thiazoles, isothiazoles, and other azole systems.

Finally, RADICAL CROSS COUPLING without the exogenous REDOX. We disclose in @ChemRxiv (chemrxiv.org/engage/chemrxi…) a broadly general platform for achieving transformations that normally required excess metallic or chemical reducing agents or photochemical setups (and their requisite catalysts) or potentiostats for electrochemistry. Now, such transformations can be accomplished with the same ease that one conducts a Suzuki coupling. You can scale up (its homogeneous) or scale down (use cheap parallel screening plates). Moisture is tolerated and base metal catalysis is used. As the best engineers like to say, "The best part is no part". Now, chemists have the option to remove the redox part from radical couplings. Quick Summary: Sulfonyl hydrazides are disclosed as versatile radical precursors as exemplified with seven new C–C bond forming, redox-neutral cross-couplings with: (1) activated olefins, (2) alkyl halides, (3) redox active esters, (4) aryl halides, (5) alkenyl halides, (6) alkynyl halides, and (7) a trifluoromethylating reagent to forge C(sp3)-C(sp3), C(sp3)-C(sp2), and C(sp3)-C(sp) bonds. Sulfonyl hydrazides are stable and usually crystalline substances that can be accessed in a variety of ways including transiently from hydrazones to achieve a net reductive arylation of carbonyl compounds. Exogenous redox (chemical, photo/electrochemical) additives are not necessary as these functional groups serve the dual role of radical precursor and electron donor. The operational simplicity (homogeneous, water tolerant, dump-and-stir) and practicality of the method are demonstrated as well as applications to streamlining synthesis and mild late-stage functionalization.

한 강 Han Kang – awarded the 2024 #NobelPrize in Literature – was born in 1970 in the South Korean city of Gwangju before, at the age of nine, moving with her family to Seoul. She comes from a literary background, her father being a reputed novelist. Alongside her writing, she has also devoted herself to art and music, which is reflected throughout her entire literary production.

Ever had a radical reaction not work when it ‘should’? Mismatched *radical polarity* may be the issue. We often only look at BDE & redox (thermodynamics), but forget polarity (kinetics). Jake, Andrew, & I are excited to share this new resource to help! pubs.acs.org/doi/abs/10.102…

Excited to present the first paper from the Park group, published today in @ScienceMagazine! We found a user-friendly, mild reaction conditions for exchanging an oxygen in heterocycles with nitrogen groups. Congrats Donghyeon, Jaehyun, and the team! science.org/doi/10.1126/sc…

🚨Appearing today in @J_A_C_S 🚨 Diverse Synthesis of C-Glycosides by Ni-Catalyzed Carboboration of Glycals pubs.acs.org/doi/epdf/10.10… If you think this method might access interesting C-glycosides for your research, please email Kevin.  We are interested in collaborations!🤝🏻

MEDICINAL CHEMISTS: Looking to increase your Fsp3? Synthesize in 3D just as you have been doing in 2D for eons by combining biocatalytic C–H oxidation and radical retrosynthesis (enabled by electrocatalysis). Appearing today in @ChemRxiv : chemrxiv.org/engage/chemrxi… . A fantastic collaboration with @hanzyduzit @YuKawamata

Happy to share our account on diverse transformations of aromatic esters at Accounts of Chemical Research @ACSPublications ! This is an open access article so please check it out! Great job Masayuki and congrats to everyone involved!! doi.org/10.1021/acs.ac…

Delighted to share our total synthesis of the purported structure of merremoside G and H2. The key coupling step doesn't require any activation, making pentasaccharide structure in much milder conditions. Check out here! pubs.acs.org/doi/10.1021/ac…

I am sad to report that Prof. Hee-Yoon Lee at KAIST passed away on Thursday (Jan 26, 2023). His leading research in the field of natural product total synthesis and his service to the (Korean and beyond) chemical society will always be remembered.

Years in the making! Every online resource for brushing up on organic chemistry (& beyond), inspired by friends who wanted job interview practice. Problem sets, group meeting slides, videos, etc. Mainly for active researchers but some intro resources too. supersciencegrl.co.uk/learning

Palladium-Catalyzed Asymmetric Decarboxylative Addition of beta-Keto Acids to Heteroatom-Substituted Allenes (Rhee) @CPostech onlinelibrary.wiley.com/doi/10.1002/an…

Starting a Masters or PhD in organic chemistry this fall? Synthesis Workshop (synthesis-workshop.com) can help you stay up to date on advances in organic synthesis! Detailed open access videos and guest talks on a wide range of topics can help you get started! RTs appreciated!