SilcsBio

Learn more about Steven and his journey in our official announcement: 👉 silcsbio.com/silcsbio-hires…

One of his notable contributions? Co-authoring “Ranking mAb–excipient interactions in biologics formulations by NMR spectroscopy and computational approaches” - a nice example of how modeling transforms formulation science. (doi.org/10.1080/194208…)

We’re excited to welcome Steven Gossert , Ph.D. to SilcsBio as our new Applications Scientist -Computational Drug Design! 🎉 Steven has been using SILCS tech for years at BMS to accelerate biologics formulation and champion model-first drug development. 👏

Using SILCS-Biologics, the GeneScience Pharmaceuticals team uncovered key protein-protein & protein-excipient interactions to design stable, ultra-high-concentration #antibody #formulations. 👏 Full paper 👉 doi.org/10.1080/194208… #SILCS #Biologics #mAbs #DrugDevelopment

Run CGenFF for Just $1 per Molecule (July Only) Industry users can now generate topology and parameters for small molecules for just $1 each. Explore #CGenFF with minimal commitment and maximum flexibility. app.cgenff.com #CompChem #MolecularModeling

Harnessing computational technologies to facilitate antibody–drug conjugate development #machinelearning #compchem nature.com/articles/s4158…

Beyond on overview of physics and ML-based methods applied to antibody-drug conjugates (ADCs) the paper presents calculations showing how MD simulations and the SILCS technology may be used to facilitate ADC development using utilities available from @silcsbio

New Perspective in Nature Chemical Biology: physics-based computational methods like MD and SILCS enable predictive, rapid design of ADCs—optimizing linker–site–DAR choices & payload–antibody interactions. #ADC #Biologics #CompChem #SILCS @alex_mackerell nature.com/articles/s4158…

⚛️ CGenFF Web App (cgenff.com) has helped 10K+ users generate topology and parameters for 100K+ molecules. Next week, a special opportunity is coming for industry users to try it with fewer barriers. 📅 Details drop July 1. #CGenFF #CompChem #GROMACS #CHARMM

KRAS G12D: Once Undruggable, Now Predictable with SILCS See how our platform delivers: 🔹 Binding site ID from apo structures 🔹 Accurate pose refinement + LGFE scoring 🔹 Atom-level SAR insights #CompChem #DrugDesign #SILCS silcsbio.com/cracking-kras-…

SilcsBio Team will be at #ACSSpring2025 🎤 #Talk by @AsukaOrr : SILCS for ADC development 📅 Sun, Mar 23 | ⏰ 4:30 - 4:55 PM 📜 #Poster by @aakognole : Speed vs. Accuracy in CADD 📅 Tue, Mar 25 | ⏰ 7:00 - 9:00 PM |📌# 865 📍Booth at #ACSExpo # 3951 #CompChem #DrugDesign

ACS Spring 2025 is just two weeks away! The SilcsBio team will be in San Diego! We’ll be at the ✅ Expo with a booth, plus we have a✅ talk and a ✅ poster session lined up. Stay tuned for details on our schedule. If you’re attending, let’s connect! 👥 #CompChem #ACSSpring2025

SILCS v2025 Release Webinar Recording is Now Available! 🎬 Missed the live session? Catch up now to explore📺: silcsbio.com/whats-new-in-s… 📄 Read full release notes: docs.silcsbio.com/2025/release.h… #CompChem #drugdesign

Register here: @2c089095-3eb5-4a8d-afe9-5b982d2697a7" target="_blank" rel="nofollow noopener">events.teams.microsoft.com/event/214c66e6…

Reminder to register! SILCS v2025 will be available starting next week. Join us to take an in-depth look.

🌟 Join Us for the SILCS v2025 Release Webinar! 🌟 Key Highlights being coverd: - Precise docking w/ water inclusion - Improved ML-based hotspot ranking - Streamlined multi-cofactor simulations 📅 Feb 13, 2025, 12 PM ET Register: @2c089095-3eb5-4a8d-afe9-5b982d2697a7" target="_blank" rel="nofollow noopener">events.teams.microsoft.com/event/214c66e6… #compchem #drugdesign

🎥 Missed the SILCS-WATER webinar? Watch the recording now! Learn how SILCS-WATER provides exciting possibilities for understanding water's role in protein-ligand interactions. 📽️ youtu.be/wrTJOzMrH2w Thanks to @anmol_aaryan and @alex_mackerell #CompChem #DrugDesign

🚀 Beta Testers Wanted for SILCS-Covalent! We've developed a new covalent workflow module to enhance drug discovery. Check out our publication: lnkd.in/e_pfyimd. Interested? Reach out at info@silcsbio.com for details and incentives!

Covalent drug design paper. Reactive Site Detection: SILCS-Monte Carlo for accurate cysteine identification. Warhead Optimization: ML models to rank warhead effectiveness. Integrated Workflow: SILCS-Covalent for comprehensive insights. pubmed.ncbi.nlm.nih.gov/37115781/

SilcsBio 2024.2 Version is officially released. Check out the new features here: lnkd.in/dgi-asCc