Silvia

La peor alumna de la historia

@Esthercj Sí!

@siljvil Hola! Tienes alguna?

VENDO DOS ENTRADAS PARA INTERESTELAR!! Abonos generales para ambos días!! Cambio de nombre no incluido 🙏🏼🙏🏼🙏🏼 (Por favor llevo mucho dinero gastado en entradas de conciertos a los que al final no puedo ir 🤡)

@RegiPha_ Sí! Al precio que las compré, 85 cada una

@siljvil Hola! Todavía las tienes? Precio?

@looree96cc Hola Lorena! Los abonos que tengo son completos, para los dos días. Ya me dices si te interesa

@siljvil Buenas estoy interesada Silvia ! Pero para el sábado solo

🚀 Excited to share my first preprint on bioRxiv:[biorxiv.org/content/10.110……] AlphaBridge simplifies protein structure predictions for experts and novices by combining complex analysis with visual representations and interactive tools in one user-friendly platform.

AlphaBridge: tools for the analysis of predicted macromolecular complexes • AlphaBridge introduces tools to analyze and visualize the interfaces between predicted macromolecular complexes using data from AlphaFold3. It processes the predicted interactions into intuitive diagrams and 3D models for easy interpretation. • The tool uses a novel “Predicted Merged Confidence” (PMC) matrix, which combines the Predicted Local Distance Difference Test (pLDDT) and Predicted Aligned Error (PAE) metrics to identify multi-component structural modules and binary interfaces with high confidence. • AlphaBridge uses graph-based community clustering to detect interaction motifs in biomolecular complexes, then visualizes these interactions as chord diagrams (“AlphaBridge diagrams”) to provide a clear and intuitive summary of predicted binding interfaces. • The tool allows researchers to evaluate the reliability of interactions in predicted protein-protein, protein-DNA, and protein-RNA complexes, offering a scoring and ranking system for predicted interfaces before detailed analysis. • By varying the cut-off for contact predictions, AlphaBridge can help distinguish between reliable and unreliable predictions, providing insights into physiological relevance. It was particularly useful for evaluating interactions in DNA mismatch repair proteins and RNA binding proteins. • The AlphaBridge webserver (alpha-bridge.eu) offers an interactive platform where users can upload AlphaFold3 prediction files, visualize the predicted 3D structures, and analyze contact interfaces through an integrated web viewer. • AlphaBridge enhances accessibility for both expert and non-expert users by combining multiple layers of information—contact links, prediction confidence, and visual representations—into one interactive diagram, simplifying the evaluation of complex predictions. @TassosPerrakis @rborza_ 💻Code: github.com/PDB-REDO/Alpha… 📜Paper: biorxiv.org/content/10.110…

Ya está aquí el #SORTEO de octubre. Póster de orbitales atómicos de dimensiones 60 cm x 40 cm. Para participar REPOSTEA. Ganador el domingo 06/10/2024 a las 22:00.

@dan_salv_ 🙄