Simon dOelsnitz

Our chemical -> biosensor prediction tool, Ligify, just came out in @ACSSynBio ! Give it a spin: ligify.groov.bio Publication here: pubs.acs.org/doi/10.1021/ac…

Just hit 150 biosensors in groovDB! groov.bio

Neat video from Research Square about our recent biosensor/ML paper vimeo.com/929916473

... Matthew Minus for chemical synthesis, James Howard for LC/MS analysis, Mason Schechter & Hannah Do for cloning support, and Hal Alper @alperlab & Andy Ellington for general support/advice.

This was a huge TEAM effort. Thank you Danny Diaz and James Loy for creating/implementing MutComputeX, Wantae Kim and Jessie Zhang for enzyme crystallography, Daniel Acosta for HPLC measurements, Tyler Dangerfield for kinetic analysis, ...

Our paper on biosensor/ML-aided enzyme engineering just came out! We're one step closer to fermenting the anti-alzheimer's drug Galantamine, rather than harvesting it from daffodils. nature.com/articles/s4146… @synbio

Excellent updated review on TetR-family transcription factors. #synbiosensors doi.org/10.1016/j.jsb.…

Development of a whole-cell biosensor for ethylene oxide and ethylene biorxiv.org/content/10.110…

Snowprint is out! Find out what specific DNA sequence your biosensor recognizes. #syntheticbiology tinyurl.com/qtdnko snowprint.groov.bio

Transcription factor evolution plasmid (pSELIS) is now available on Addgene. addgene.org/202631/

Preprint of our new tool for predicting biosensor-DNA interactions is out. We use it to discover sensors for a cannabinoid precursor, among others. Check it out! biorxiv.org/content/10.110…

Can #synbio help us brew an Alzheimer's drug currently harvested from daffodils? Just got 1 step closer. 🌼🧠🦠 doi.org/10.1101/2023.0…

Now we know what is the rate limiting step in LAMP, which will enable even faster diagnosis of diseases via LAMP. academic.oup.com/nar/advance-ar…

@Moon_Synth_Bio @ACSSynBio Glad to hear! We are working hard to improve it further.

Useful tool @ACSSynBio GroovDB: A Database of Ligand-Inducible Transcription Factors pubs.acs.org/doi/10.1021/ac…

Big thanks to Josh Love and @aiproteins for making this possible!

Tired of searching the literature for genetic sensors? Check out our biosensor database (groov.bio), now published in @ACSSynBio doi.org/10.1021/acssyn…

Just put out a pre-print on a database of genetic biosensors I put together (groov.bio). Hope it's useful to the syn bio / bioengineering community! Feel free to message me with feedback. doi.org/10.1101/2022.0…

+1 biosensors, -1 chromatography! My work on evolving biosensors for therapeutic alkaloids is now out in @nchembio rdcu.be/cRb3T #synbio #biotech #biosensor

Recently published in @ACSSynBio ! doi.org/10.1021/acssyn… #scicomm

Terpenes are hard to measure. Genetic biosensors can help. Here, we evolve biosensors responsive to fragrant monoterpenes. #biotech #synbio #biosensor #directedevolution biorxiv.org/content/10.110…