Srijith Sasikumar

🚨 New preprint! Which spatial deconvolution & domain detection methods should you actually use? We benchmarked 21 deconvolution + 18 domain detection methods across 21 tissue types, including brain, cancer & organs — the largest study of its kind. biorxiv.org/content/10.648…

Here's a story. About yeast. And I swear, this story is about more than just what happens inside your bread. Let's begin. nature.com/articles/s4146…

@AthiNaganathan @NatureComms @Himanshu_IITM @iitmadras @IBSE_IITM @iitmbt @DTUBiosustain Thank you sir :)

@srijithbt @NatureComms @Himanshu_IITM @iitmadras @IBSE_IITM @iitmbt @DTUBiosustain Congratulations! :) Looking fwd to more

🚀 Excited to see my PhD research published in @NatureComms! Grateful to my supervisor @Himanshu_IITM, the incredible Systems Genetics Lab @iitmadras @IBSE_IITM @iitmbt and collaborators Suresh Sudarsan & Shannara @DTUBiosustain for making this possible.

Researchers at @iitmadras and the Technical University of Denmark (@DTUtweet) have discovered how interactions between genetic variants act as “switches” that unlock hidden metabolic pathways. Published in Nature Communications, the study shows how two yeast variants, when combined, activated a dormant arginine biosynthesis pathway, reprogramming metabolism and proving that genes working together can create entirely new outcomes. This breakthrough offers critical insights into complex diseases like cancer, diabetes, and neurodegenerative disorders, paving the way for personalised medicine with more precise biomarkers and drug targets. Beyond healthcare, the findings hold promise for synthetic biology, microbial engineering, and precision agriculture, where engineered gene interactions could improve biofuels, pharmaceuticals, and crop resilience. The discovery redefines our understanding of gene–gene interactions and opens new frontiers in healthcare and biotechnology. #IITMadras #Genetics #Innovation #Research #PersonalisedMedicine

Thrilled to share our new paper in @NatureComms! “Interaction of Genetic Variants Activates Latent Metabolic Pathways in Yeast” Led by PhD student @srijithbt with @DTUBiosustain collaborators Suresh Sudarsan & Shannara Taylor Parkins.🔗 nature.com/articles/s4146… 1/5

Check out our latest work in developing open-source foundation models for de novo drug design. Stay tuned for the accompanying blog post and starter notebook. @iitmbt @WSAI_IITM @IBSE_IITM @iitmadras

A single-cell atlas of ribosomal protein heterogeneity across human tissues reveals phenotypes of biological and clinical significance biorxiv.org/content/10.110… #biorxiv_sysbio

Excited to share our latest from the Systems Genetics Lab @iitmbt published in npj Systems Biology and Applications @Nature_NPJ rdcu.be/emNld! We used genome-scale metabolic models (GEMs) & transcriptomics to reveal how SNP-SNP interactions (1/4)

Genetic interactions can activate unique pathways & modulate complex traits. Our @srijithbt multi-omic study on yeast sporulation reveals how 2 SNPs can trigger metabolic trade-off by increasing amino acid metabolism & downregulating ribosome biogenesis... x.com/biorxiv_sysbio…

@liti_nice Viswa Chaithanya, first graduate student from Systems Genetics Lab @iitmbt shows in this paper that a common variant in a pleiotropic gene MKT1 regulates multiple stress responses via Pbp1 and Puf3 dependent manner. (1/n)

Multi-SNP combination genome-scale metabolic models identify molecular mechanisms determining genetic interactions in a quantitative trait biorxiv.org/content/10.110… In this paper, we @srijithbt address how multiple SNPs of a quantitative trait interact... 1/4

Genetic architecture of phenotypic plasticity can be determined using the #yeast model. In this @TrendsGenetics review, we describe how single gene deletion, SGA and QTL studies inform us about additive & epistatic architecture (1/3) authors.elsevier.com/a/1h34vcQbJ7Wm…

Welcome to the 4th #IBSE International Symposium with exciting and interesting talks on #microbiomes in environment, space and in human health! #IBSE #IBSESymposium #IITM_microbiome #IBSE4microbiome

Where on the map are you today?😂 #AcademicTwitter

read this & share. @VoicesofIndAcad @PhDsofIndia @PhDStudents @KaushikLab @MBLScience @PhDVoice @iiscbangalore @NCBS_Bangalore @WormlockHolmes @uniofeastanglia @Cambridge_Uni science.org/content/articl… #gradschool #PhD #phdlife #mentalhealth #MentalHealthAwarenessWeek