Silke Heinzmann

@BiswapriyaMisra Exactly thats what my literature research suggests, too. High acetate -> infection/injury/… However the patients were all perfectly healthy.

@ssHeinzmann As I read here: “N-acetylneuraminidine (NeuNAc), N-acetylglutamine (GIcNAc) and acetate are metabolites present in normal urine. In patients treated with aminoglycosides and/or glycopeptides, elevation of these metabolites in urine suggests renal tubular injury.”

To all #metabolite #metabolomics #biochemistry experts out there: Why would urinary acetate increase (no bladder/kidney infection)? 🙏

@drchrispook Free acetate. As seen with NMR spectroscopy. Acetylated metabolites would habe a slightly different chemical shift.

@ssHeinzmann By 'acetate' do you mean free acetate anions or acetylated metabolites?

And yes I made the wrong choice, though pretty picture from above Hamburg

Munich to Kiel by plane and train: S-Bahn Munich - airport☺️, plane MUC - HAM ☺️, S-Bahn HH 😷, train HAM - Kiel 😷, Kiel bus ☺️, 5.5h, carbon footprint 0,17t All by train 😷, 7.2h, carbon footprint: 0 #lifeiscomplicated 😷vs⏰vs👣🌿

@draftery2 @nmr900 Very nice work!

We have some new work out on detecting almost 90 blood metabolites by NMR quantitatively: reader.elsevier.com/reader/sd/pii/… #metabolomics, #NMR

@LenaKeller01 @angew_chem @Helmholtz_HIPS Great paper! 🧲

Want to know how soil bacteria from a hot desert in Iran can help us fight coronaviruses? Check out our newest publication @angew_chem! Spoiler alert: Cool molecules @Helmholtz_HIPS onlinelibrary.wiley.com/doi/10.1002/an…

On my way back to @HelmholtzMunich after a visit to BNMRZ and @Sattler_lab. Thanks for having me and for lively discussions 💡on NMR 🧲 Metabolomics 💪 . @ChemBioSys_muc

🤔 Having trouble identifying unknown metabolites in urine samples? 💡 Take lots of urine samples (e.g. a human cohort), a #NMR 🧲spectrometer, our new 📝workflow and identify microbial vs endogenous #metabolites! ➡️ t1p.de/5x3qu @MetabolitesMDPI A thread 🧵

7/ Thanks to all co-authors for great support! @ChemBioSys_muc @Schmitt_Kopplin Melanie Waldenberger Annette Peters (@EPI_Helmholtz) @HelmholtzMunich

6/ What’s new? 1) We suggest to add the CLASSY analysis to the 🧲NMR metabolomics identification workflow 2) We suggest a data-driven classification of metabolites to microbial vs endogenous origin 3) We identify several microbial and (potential) coffee biomarkers in urine

Munich #Metabolomics Meeting happening now! Excited to meet friends and colleagues here ✨in person✨! My talk is over now I am looking forward to discussions and the other speakers 🤩

A LOT of work by multiple team members and collaborators ⭐️ turned into a nice manuscript @CellPressNews describing the expanded mouse intestinal bacterial collection (miBC)⭐️: doi.org/10.1016/j.chom…. A thread summarizing this resource that we hope will be useful to many. 01/16

Out now! Plasma metabolomics was readout of an individual’s genetics, the gut microbiome and diet. A team work of ⁦@LifelinesNL⁩ ⁦@UMCGgenetica⁩ ⁦@GroMicrobiome！ nature.com/articles/s4159…