Sam Sgrizzi

Thrilled to share that EVOLVEpro is now published @ScienceMagazine Since our preprint, we now demonstrate low-N eningeering of both antibody and enzymes. We hope this model will broadly useful to the protein engineering field. science.org/doi/10.1126/sc…

Directed evolution won a Nobel prize by unlocking new protein functions How can we augment evolution to engineer proteins 10-100 times better? By using large language models! Here we present EVOLVEpro, an LLM for accelerated protein evolution biorxiv.org/content/10.110… 1/

@zhaoweiasu @connorjtou @biorxivpreprint @FerreiraSilvaJ 🤖

@connorjtou @biorxivpreprint @FerreiraSilvaJ Connor, very cool work on prime editing variations!

Today in @biorxivpreprint, we introduce Click Editing - which combines DNA-dependent polymerases, HUH endonucleases, and RNA-programmable nickases for versatile human genome editing without double-strand breaks. Co-led with @FerreiraSilvaJ 🤝🧬 (1/15) biorxiv.org/content/10.110…

CRISPR nucleases have been transformative. What if there were similar RNA-programmed nucleases in eukaryotic genomes? Turns out, they are abundant (>3500) and functional! Today we share findings on novel RNA-guided DNA nucleases in eukaryotes. biorxiv.org/content/10.110… 1/14