StemCellReports

Online now! Mitochondrial toxins cause widespread downregulation of pathways in X-linked dystonia-parkinsonism patient-derived neurons. ow.ly/bFvJ50YXPfa @CellPressNews @GairdnerAwards @SickKidsNews

New review explores screening strategies, ML-enabled readouts, and advantages over traditional models, while addressing major challenges like scalability, robustness, throughput, and standardization needed for pharma adoption. ow.ly/uGqn50YXP6B

NRG-1 restoration reactivates NPCs & fosters hippocampal repair by supporting neurogenesis, neuronal complexity, synaptogenesis, & remyelination that reverses memory loss in mice with progressive brain demyelination👉 bit.ly/4t9sB6K @ISSCR @CellPressNews @ShivaNemati82

Stem Cell Reports, @ISSCR's open-access, peer-reviewed journal, has been named the Official Conference Journal of the BaCell 3D Organoid Conference, taking place 22-24 June 2026 in Basel, Switzerland. Read more 👉 ow.ly/yn7R50YRJhJ

TOE1 is a β-catenin interacting protein and novel regulator of hematopoietic cell proliferation through PAK2 modulation ow.ly/MlvB50YP49P @ISSCR @CellPressNews @GairdnerAwards @SickKidsNews @SussexUni @BSMSMedSchool @uhsussex @UniofOxford @pauedutr

Researchers at Karolinska Institutet and KTH Royal Institute of Technology have developed an improved method for creating insulin-producing cells from human stem cells. Learn more at @stemcellreports 📝: bit.ly/4cvy9TS 📰: bit.ly/4ty3wmS

We’ve discovered a new stem cell regulator! Published today in @stemcellreports, fantastic work from joint lead authors @hyun_park7 and @oknsvm identify TOE1 as a novel regulator of acute myeloid leukaemia (AML) and HSC proliferation/survival. 🧵 👇 1/ cell.com/stem-cell-repo…

Read a joint collection from @CellStemCell and @stemcellreports (@ISSCR) highlighting studies developing vascularized tissue models hubs.li/Q04bVrkn0 @GairdnerAwards @SickKidsNews

Microvessel co-transplantation improves poor remuscularization by hiPSC-cardiomyocytes in a complex disease model of myocardial infarction and type 2 diabetes hubs.li/Q049ypTj0 Article highlight from @stemcellreports (@ISSCR) @UHN

Check out this new #organoid research in Stem Cell Reports: MECP2 mutations rewire human embryonic stem cell fate and bias cortical lineage commitment ow.ly/wZ5a50YP3V8 @ISSCR @CellPressNews @GairdnerAwards @SickKidsNews @ChuSteJustine @umontreal

3D vessels-on-chip using isogenic hiPSC-derived VSMCs reveal NOTCH3-driven alterations in brain small vessel disease hubs.li/Q049yrqv0 Article highlight from @stemcellreports (@ISSCR)

New paper provides ultrastructural and 3-D features of ventricular-subventricular zone (V-SVZ) neuroblasts in postnatal microminipigs, establishing them as a tractable gyrencephalic model for postnatal neurogenesis. ow.ly/cNTP50YKv4N @ISSCR @GairdnerAwards @SickKidsNews

Online Now! An optimized protocol for efficient derivation of pancreatic islets from multiple human pluripotent stem cell lines that enables production of highly functional stem cell-islets suitable for type 1 diabetes cell therapy. ow.ly/wHuk50YKuVL

In this anniversary episode, Janet Rossant is joined by a few of our past guests who helped define the conversations of the past five years. Revisit where their work stood then, explore where it has gone since, & take a closer look at what lies ahead 👉ow.ly/EVj050YJ0Y6

Check out this new intestinal #organoid research: Phenotypic screening identified that glycyrrhizin confers protection against tumor necrosis factor-induced cell death, which may be a novel therapeutic compound for Crohn’s disease. ow.ly/onGW50YKuMz

Congrats to Hisato Iriki and Samuele Marro (primary corresponding PI) on this paper which is now accepted at @stemcellreports! Thanks to all our collaborators including those at @abbvie who made this possible. iPruriceptors from Pluripotent Stem Cells biorxiv.org/content/10.110…

iPSC-Derived Endothelial Cells Affect Vascular Function in a Tissue-Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome hubs.li/Q049yg6W0 Article highlight from @stemcellreports (@ISSCR) @DukeUBME

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The Stem Cell Report Podcast celebrated its 5 year anniversary and welcomed back past guests to revisit where their work began, explore how it’s evolved, and look ahead to what’s next. @ISSCR @martinperaJAX @TheFlorey @KECKSchool_USC @USCStemCell @ucsdneurodept

Read a joint collection from @CellStemCell and @stemcellreports (@ISSCR) highlighting studies developing vascularized tissue models hubs.li/Q04bVvZg0 @GairdnerAwards @SickKidsNews