Justin T Biel

It blows me away that @UCSF is out here fighting for open access for all UC papers in @ElsevierConnect but wants to charge me extra to make my thesis open access.

New #preprint in #bioRxiv. Directional conformational cycling of enzymes out of equilibrium #fljcnlt twitter.com/MichaelKGilson…

.@fraser_lab Modeling an unbound + ligand-bound ensemble improves crystal structures: biorxiv.org/content/early/… #fljcnlt #preprint #biorxiv

Flexibility and design: conformational heterogeneity along the evolutionary trajectory of a ... biorxiv.org/cgi/content/sh… #bioRxiv

.@fraser_lab #fljcnlt 2nd-shell mutations enhancing phosphotriesterase function of promiscuous AiiA lactonase ncbi.nlm.nih.gov/pubmed/?term=2…

.@fraser_lab #fljcnlt Biophysical study of water dynamics extending from protein-water interface. ncbi.nlm.nih.gov/pubmed/27339138

World's biggest laser gets an upgrade: ✔1000x more powerful ✔10000x brighter ✔8000x faster 1.usa.gov/28LF8s4 amp.twimg.com/v/7df75f01-235…

.@fraser_lab #fljcnlt Changes in active site water upon mutation in Aristolochene synthase ncbi.nlm.nih.gov/pubmed/?term=2…

.@fraser_lab #fljcnlt Studying the conformational states of a highly flexible loop in Indoleamine dioxygenase ncbi.nlm.nih.gov/pubmed/?term=2…

.@fraser_lab Using kinetic crystallography to study the dynamics of insect carboxylesterase. sciencedirect.com.ucsf.idm.oclc.org/science/articl… #fljcnlt

.@fraser_lab #fljcnlt The other side of macromolecular crystallography - the solvent. ncbi.nlm.nih.gov/pubmed/25945568

.@fraser_lab #fljcnlt R factor gap in macromolecular crystallography - inadequacies of current models ncbi.nlm.nih.gov/pubmed/?term=2…

.@fraser_lab #fljcnlt Ordered solvent positions for each amino acid in different conformations ncbi.nlm.nih.gov/pubmed/26527137

.@fraser_lab #fljcnlt MUMO: minimal underfitting and overfitting: ubiquitin ensemble #PDB:2nr2 ncbi.nlm.nih.gov/pubmed/17225069

.@fraser_lab #fljcnlt Maximum entropy and maximum caliber review journals.aps.org/rmp/abstract/1…

.@fraser_lab #fljcnlt Improved prediction of stable sequences using negative multistate design ncbi.nlm.nih.gov/pubmed/26412333

.@fraser_lab #fljcnlt Fundamental challenges in determining contributions to enzymatic rate enhancements vs solution ncbi.nlm.nih.gov/pubmed/23488725

.@fraser_lab #fljcnlt Dynamics and catalysis of cyclophilin proteins ncbi.nlm.nih.gov/pubmed/26335054

.@fraser_lab #fljcnlt Positioning of the catalytic base in ketosteroid isomerase ncbi.nlm.nih.gov/pubmed/24597914

.@fraser_lab #fljcnlt Comparing models with variable number of parameters using information criterion: AICc and BIC smr.sagepub.com/content/33/2/2…