David Vilchez

New work from the lab @NatureAging!❄️Lowering body temperature extends #longevity. We find that cold-induced #proteostasis prevents #aging and aggregation of proteins that cause age-related diseases #ALS #HuntingtonDisease in C. elegans and human cells nature.com/articles/s4358…

Bridging omics and physiology to build multimodal clocks of human aging: Cell cell.com/cell/fulltext/…

@PlantoPhagy Wow! Super cool, Yasin and team!

Take-home message: autophagy promotes cellular survival by preventing excessive cell death during viral replication.

@Team_Zuccaro @neto_flames @JohanaMisas Super cool work!

Really proud of this collaborative work exploring how fungal effectors exploit prion-like domains to access plastids and influence plant metabolism during symbiosis. Great to see the PEPSI–DXR story come together. @neto_flames @JohanaMisas @TheVilchezLab biorxiv.org/content/10.648…

Great collaborative effort by: Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, and Seda Koyuncu @CECAD_

The review covers proteostasis mechanisms across major organelles: • Nucleus • Mitochondria • Endoplasmic reticulum • Golgi apparatus • Lysosomes We also highlight proteostasis in membraneless organelles: • Stress granules • P-bodies • Nucleolus • Nuclear speckles

Our new review on proteostasis of organelles in aging & disease is now online in The FEBS Journal! We discuss recent insights on how #proteostasis safeguards organelle integrity and function across the cell in #aging and disease doi.org/10.1111/febs.7…

@NornGroup Thank you so much for all your support!

Toxic protein aggregation is a hallmark of Huntington's, ALS, Parkinson's… and enhancing the cell’s natural protein-clearing machinery is a promising therapeutic avenue. @TheVilchezLab at CECAD/University of Cologne studies how protein homeostasis breaks down with age and how stem cells maintain proteome integrity where somatic cells fail. We funded them via @impetusgrants to study toxic protein accumulation and discover ways to reduce those protein aggregates. @TheVilchezLab's Nature Aging paper (supported by @impetusgrants) showed that cold temperature selectively activates PA28γ/PSME3, a proteasome activator required for cold-induced longevity. This reduced disease-related protein aggregation in both C. elegans and human cell models of Huntington's and ALS. His team continues to explore how we might harness these proteostasis mechanisms to prevent age-related neurodegeneration. Glad to support this work!

@BarakRotblat Thank you Barak!

@TheVilchezLab Congrats David and co!👏👏

🚨 New from our lab: Here we explored how aging contributes to harmful protein aggregation in diseases like Huntington’s & ALS. The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch 🧵 nature.com/articles/s4358…

A titanic effort from Seda and the lab in collaboration with Nuria Flames’ lab @sedakoyuncu12 @CECAD_ @UniCologne @UKKoeln @IBV_CSIC @NatureAging

We also discovered that the deubiquitinase USP4 leads to EPS8 accumulation during aging. Reducing USP4 prevented EPS8 accumulation, extended lifespan, and lessened disease effects. 👉 Targeting EPS8/USP4 could open new therapeutic strategies for neurodegeneration.

New work from the lab! C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules - Bilican - FEBS Letters - Wiley Online Library febs.onlinelibrary.wiley.com/doi/10.1002/18…

@Mucus_Man Congrats!

🚨While the world is burning down around us, I'm happy to share that I've been promoted to Associate Professor with tenure. Though this is considered a personal achievement, it was only possible due to the wonderful trainees in the lab, who carried me here❤️.

@rushika_perera @RosaMenjivarPhD @kioneillphd @GillesRademaker @graceah9 @marineberquez @YangYan55648779 Congrats!!!!

Promoted ! 🙌

@ramonterrats_ @RCDEspanyol Benvingut a la teva casa!

Els somnis es fan realitat 💙🤍, @RCDEspanyol

@CdCiudadDZamora Pero que locura es esta?🤪🤪

We have a 4-year postdoc position open in our Research Unit on proteostasis! The project explores inter-tissue regulation using advanced proteomics approaches. Collaborative & interdisciplinary environment. More details & application here: jobs-uk-koeln.onlyfy.jobs/job/pktg6ivjss…

@AsAshraf123321 Thank you Ashraf!

@TheVilchezLab Congratulations 🎊

Thrilled to announce that our DFG Research Unit on cell-autonomous regulation of proteostasis has been approved for funding! #aging #proteostasis cecad.uni-koeln.de/outreach/news/…