Tim Weber
494 posts
@timdweber
Building microscopes and methods to detect cancer and improve surgery. @RLEatMIT & @BIDMCpath
Excited to share 2p-prime, a novel physical pathway for multiphoton fluorescence generation that enables optical sectioning and excitation at red wavelengths with simple systems like continuous wave lasers. I founded @tripletimaging with @jdwong_campos to fully realize the potential of this tech and introduce a new paradigm for multiphoton fluorescence. We’re exciting real intermediary states, specifically driving forbidden triplet transitions, using picosecond and continuous wave lasers. Links to two pre-prints + explanation in the thread where we demonstrate 2p-prime with ps and CW lasers in dyes and living cells expressing fluorescent proteins. David thought of this idea, inspired by optical control of forbidden state transitions in atomic systems from his past life in quantum computing in the Monroe lab and as an early employee at @IonQ_Inc. In the limit, our approach could be optimized to replace all fluorescence microscopes with simple LED systems that can do rapid volumetric imaging with capabilities akin to existing 2p systems in optical sectioning, contrast, depth, and resolution. Low power, high throughput multiphoton imaging could enable moonshots like functional imaging of every synapse on a neuron or single cell resolution across an entire mouse cortex — datasets which are inaccessible now due to high powers required by ultrafast lasers. Fundamental insights may generate broad possibilities, and we’re investigating applications across multiple industries like diagnostics and 2p lithography. This is a white space in photophysics. No indicators have been designed or evolved for this process. We’re optimistic we’ll keep lowering power levels as indicators are optimized for these transitions, e.g. enhanced spin-orbit coupling.
I'm with @DrLauraEsserman on this: rename very low risk "#cancer" like IDLE = indolent lesions of epithelial origin (breast, prostate, and others) bmj.com/content/364/bm… @bmj_latest stop the unnecessary surgery, treatment and alarm/anxiety
A new congressional blueprint for restructuring the NIH has been released. It proposes consolidating NIH's 27 IC's and centers into 15 categories, plus term limits for directors. It adds a national security review to grant apps. Public comments due Aug. 16 energycommerce.house.gov/posts/chair-ro…
🚨#BREAKING: Search results for ‘Why do my eyes hurt?’ and ‘My eyes hurt’ have exploded after the total solar eclipse occurred
Voltron 1&2 are excellent voltage indicators, combining the sensitivity/targeting of genetically encoded microbial rhodopsin with the approaching-perfect photophysical performance of engineered organic dyes. However... (gif: doi.org/10.1038/s41593…)
@timdweber @Thorlabs @PodgorskiLab @brunopichler @Labrigger @ptrrupprecht Many years ago, I started using telescopes composed of a f=90 mm achromat and a 19 mm @TeleVueOptics Panoptic eyepiece made for amateur astronomers for the 5 mm GAsPs detectors.
