sweaty baby

Greece truly has me glowing ✨

the australian dream

people who get off at my bus stop have a certain wisdom all too rare in the world today. people who get off at the bus stop before mine are doubtless idlers. people who get off at stops after mine have ways that are foreign and uncertain but one imagines idolatrous

Spouses of Alzheimer's patients are 6 times more likely to develop Alzheimer's themselves. They share daily saliva exchange for decades. Their oral bacteria converges to the same strains. In 2019 Cortexyme published a paper in Science Advances showing Porphyromonas gingivalis, the bacterium behind gum disease, was present in over 90% of postmortem Alzheimer's brains. They also found its DNA in the cerebrospinal fluid of living Alzheimer's patients. P. gingivalis is the keystone pathogen of periodontitis. The CDC says 47% of American adults over 30 have periodontitis right now. The mechanism is specific. P. gingivalis produces enzymes called gingipains. Two types: one cuts proteins at lysine residues, the other at arginine. Tau, the protein that holds your neuronal scaffolding together, is loaded with both amino acids. In cell culture, gingipains shred soluble tau within one hour of infection. The fragments seed the paired helical filaments that become tangles. Tangles are Alzheimer's. Mice fed P. gingivalis through the mouth grew amyloid plaques in their brains. Hippocampal neurons died. The bacteria crossed the blood-brain barrier and started chewing through the same proteins that fail in human Alzheimer's patients. Cortexyme built a drug called atuzaginstat to block gingipains. Phase 1 was clean. They ran a 643-patient Phase 2/3 trial called GAIN. The FDA hit it with a partial clinical hold for liver toxicity. The drug missed both primary endpoints. In August 2022 Cortexyme shut the program down, renamed itself Quince, and pivoted to bone disease. The subgroup with the highest baseline P. gingivalis loads still showed cognitive improvement on secondary endpoints. The bacteria itself kept showing up in postmortem brains across independent studies after the trial closed. Periodontal disease shows up 10 to 20 years before cognitive symptoms in people who later develop Alzheimer's. By the time someone forgets a name, the bacteria has been working for two decades. The intervention point is upstream of your skull.

I wrote 8k words on how to manage ADHD

"its so hard sailing at night,, if only something could light my way,,," the humble lighthouse:

sufjan stevens’s “piss poems” were discovered and posted on tiktok recently by @/greenwitchwh0re this was a collection of poems he wrote in college surrounding his pissadventures

I just read the new Haaretz article about how Israeli planted pines are suddenly dying en masse and it is absolutely worth dissecting. Here are a summary & my observations as a Palestinian scholar who writes on green colonialism. 1/

@glorp999 Hahaah, look - I love being in the third city and getting to point my finger away without any introspection heheh

@toe_mass oh my can’t argue tho have u seen some of the brisbane takes?

Reposting because I need a faster way of showing this to people all the time to help explain the difference

Hey Diva 👋 I hope it’s not too late 😅💛

DJ Hell and The Hacker pick electroclash's key anthems between 1997 and 2001, revisiting the sub-genre still rocking dance floors today. Read in full now: ra.co/features/4493

Realest shit I ever seen

@Remdelarem Lol, excuse this parasocial moment, but you feel like the epitome of NYC to me so it's always such a gag when you post photos or references to the fact you live in Australia for a lot of the year hahaha

adhd being a circadian rhythm disorder (as well as other things) should be talked about more

She took a photo of her baby leaving for school, probably marveling at how fast kids grow up. Sent him with a packed lunch and all his books. And he was murdered before she could see him again. I cannot take the cruelty. May Allah ease her pain 💔

Hahhahahhahahhahahaha

By majority, High Court of Aust extends non-delegable duty of care to intentional torts, restoring AA's verdict against Diocese of Maitland-Newcastle: hcourt.gov.au/sites/default/… #auslaw

Mother was tugging on Beyoncé’s wig in the early 2000’s

Sweetpea’s ep next week yessss

The official teaser trailer for Boots Riley’s ‘I LOVE BOOSTERS’ has been released. Starring Keke Palmer, Naomi Ackie, Taylour Paige, Poppy Liu, Eiza González, LaKeith Stanfield, Will Poulter, Don Cheadle and Demi Moore. In theaters on May 22.