UCSD Sanford Stem Cell Institute

SSCI’s Alexis Komor, PhD, and colleagues created an improved version of a gene base editor with higher efficiency minimizing unwanted bystander edits - enhancing 🧬 gene editing & disease modeling for treating genetic disorders. Learn more @ bit.ly/4sms8hU @NatureBiotech

40% of Americans have metabolic syndrome, which carries with it the risk of liver fibrosis (MASH). Treatment options are limited but expanding, thanks to the work of SSCI's Tatiana Kisseleva, MD, PhD; Gene Yeo, PhD; & colleagues: bit.ly/4bsWDvs. @yeo_lab @sbpdiscovery

How will AI reshape public health and decision-making? In our latest 🎙️podcast, @bruce_y_lee , MD, MBA, shares insights on the intersection of AI, systems modeling and health communication systems. Watch here bit.ly/4sDUAeI or listen where you find podcasts. #MedTwitter

🎉 A patient w/Pitt-Hopkins syndrome has received an investigational, 1st-in-human gene therapy, thx to the lab of SSCI's Alysson Muotri, PhD. It's the first drug developed using brain organoids — and not animal models — to reach clinical trial. 🧠 H/t @UCSDMedSchool @PittHopkins

💡Sanford Stem Cell Innovation Center Deputy Director Alexis Komor, PhD, was honored Friday w/the @PMWCintl Luminary Award for co-inventing #CRISPR base editing. 🌟 SSCI Director Catriona Jamieson, MD, PhD, received the award in 2024. @KomorLab @thejamiesonlab @ucsdbiosciences

SSCI Director Catriona Jamieson, MD, PhD, recently attended the @UCSDMedSchool's Summer Research Symposium. “It’s essential for students to conduct research, particularly medical students who will someday see patients,” she said. More: bit.ly/4rjKDCd @JamiesonLab #Cancer

Congrats to SSCI’s Ludmil Alexandrov, PhD, leading Team CAUSE, awarded $25M from @CancerGrand, to decode mutational 🧬 DNA signatures or “fingerprints” that may reveal how cancer begins, informing potential treatments. 🔬 Learn more bit.ly/4r7if63. #Cancer #MedTwitter

This #RareDiseaseDay, we’re proud to spotlight 5 rare disorders & 4 researchers turning hope into reality for patients w/CPS1D, T-cell acute lymphoblastic leukemia, ALS and Rett & Pitt-Hopkins syndromes: bit.ly/3N8UqNk. @yeo_lab @KomorLab @thejamiesonlab @rarediseaseday

🦓 This #RareDiseaseDay, we’re proud to spotlight 5 rare disorders & 4 researchers turning hope into reality for patients w/CPS1D, T-cell acute lymphoblastic leukemia, Rett syndrome, Pitt-Hopkins syndrome & ALS: bit.ly/3N8UqNk. @rarediseaseday @RareDiseases @GlobalGenes

This #RareDiseaseDay, we’re proud to shine the spotlight on 5 rare disorders & 4 researchers turning hope into reality for patients w/CPS1D, T-cell acute lymphoblastic leukemia, Rett syndrome, Pitt-Hopkins syndrome & ALS. More: bit.ly/3N8UqNk. #RareDisease #MedTwitter🦓

🚀 Catch up on the latest advances in #space-related #stemcell #science & #regenerativemedicine @ our Global Astrobiotechnology Hub event THIS MONDAY, March 2, 2-6 p.m. PT. 🧫 Complimentary online tix @ bit.ly/4bhqpol. H/t @JenniferBuchli @AstroPeggy #MedTwitter

🚀 The longest-running biologic experiments in #microgravity are returning to Cali's #space coast! 🧫 When @SpaceX CRS-33 undocks from @Space_Station, it carries w/it SSCI #research payloads on stem cell resilience & neurodegenerative dz. 👀 for updates here & in medical lit. 👍

🚀 Just dropped, our new podcast🎙️with Alysson Muotri, PhD. We explore the intersection of #stemcells, medicinal Amazon Rainforest discoveries, Neanderthal DNA, space-based research and disease remodeling - all reshaping how we understand human health.🧬 bit.ly/46tGJiF🎧

🔬 #genetherapy holds incredible promise but carries the risks of immune response & toxicity. To combat this, SSCI's Alexis Komor, PhD, & team developed a workflow that allows scientists to more effectively deliver less DNA. More: bit.ly/46d1f72 H/t @NaturePortfolio 🧬

Catch up on the latest advances in #space-related #stemcell #science & #regenerativemedicine @ our Global Astrobiotechnology Hub Event on Monday, March 2, 2-6 p.m. PT. Complimentary online tix @ bit.ly/4bhqpol. H/t @JenniferBuchli @maxhaot @AstroPeggy #medtwitter #STEMed

💔 After a heart attack, scar tissue prevents a fatal rupture. But it can't contract or conduct electrical signals, significantly raising the risk of heart failure. More on an innovative solution from SSCI’s @ChristmanLab here: bit.ly/3MMwuze. 💓 #MedTwitter #hearthealth

SSCI’s Gene Yeo and collaborators developed Ribo-STAMP technology tracking protein production in single brain cells. Their @Nature study maps the brain’s “translatome,” revealing differences in memory neurons & new clues to disorders like autism. @yeo_lab bit.ly/3MkKQ9X

Carol, call us. We have ideas. bit.ly/4rUc1az #Pluribus H/t @rheaseehorn

Can the #hivemind use Carol's frozen eggs to assimilate her? Our @RobSigner, PhD, separates stem cell fact from fiction in the remarkably plausible @AppleTV blockbuster #Pluribus. bit.ly/4rUc1az H/t @SignerLab @UCSanDiego #sciencefiction #Entertainment

Tune in to learn about innovative stem cell biology trends in our latest reGEN Podcast 🎙️ conversation with @TiffaniManolis from @thermofisher. Watch here bit.ly/3MApmFZ or listen where you find your podcasts.