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Linh

@ulinhho

Scientist

Switzerland Katılım Eylül 2018
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Genetics Society of America
Genetics Society of America@GeneticsGSA·
Did you know we have a Twitch? If not, you can stop by our stream tomorrow at 3 p.m. EDT to learn what we're all about. Members of the Early Career Leadership Program will be discussing the program and why you should join! twitch.tv/geneticsgsa
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Alex Cagan
Alex Cagan@ATJCagan·
Uyen Linh Ho on assessing missense mutation effects at scale #eshg2023
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Yolanda Schaerli
Yolanda Schaerli@YSchaerli·
Early bird registration ends at the end of the month. Don't miss it! It will be an exciting meeting.
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Jolanda van Leeuwen
Jolanda van Leeuwen@jsvanleeuwen·
More details on all of this in the paper. We are collecting feedback from the community before submitting this to a journal, so if you have any comments, please let me know!
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Jolanda van Leeuwen
Jolanda van Leeuwen@jsvanleeuwen·
Did we learn enough about suppressors from this study to be able to predict them? Yes -- for about half of query genes we can predict suppressor genes reasonably well. For the other half, we'll still have some work to do!
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Jolanda van Leeuwen
Jolanda van Leeuwen@jsvanleeuwen·
We next had a look at cancer cells, which generally accumulate lots of passenger mutations. We found that damaging passenger mutations in query genes are more likely to persist in a tumor if they are accompanied by mutations in the corresponding suppressor gene
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Jolanda van Leeuwen
Jolanda van Leeuwen@jsvanleeuwen·
So what are these suppressor genes? We found that there are many ways in which suppression can occur -- and that the underlying mechanisms of suppression can tell you something about disease pathology
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Jolanda van Leeuwen
Jolanda van Leeuwen@jsvanleeuwen·
As expected, the query genes were generally intolerant to loss-of-function mutations in the human population or in cultured cells. But to our surprise, so were the suppressor genes, in apparent contrast with their protective role in the presence of the query
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Jolanda van Leeuwen
Jolanda van Leeuwen@jsvanleeuwen·
@betulunlu86 and @ulinhho read 2,400 papers (!!) to look for cases in which the deleterious effects of a "query" mutation (for example a disease mutation) were rescued by a "suppressor" mutation elsewhere in the genome. They found 476 different examples
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Yolanda Schaerli
Yolanda Schaerli@YSchaerli·
Thanks to everyone who supported the team throughout the year. Most importantly, the fantastic supervisor team @hadiastri_k @Emanuele__Boni @SJSeekles @BobbyAV @a_chhun and @ulinhho. Thanks also to @DMF_UNIL, @FBM_UNIL @ecolebiolunil and all the sponsors!
Yolanda Schaerli@YSchaerli

Congratulations to the UNIL iGEM team @IgemUnil for a gold medal, three nominations (best wiki, best new basic part, track award “environment project”) and being in the top 10 overgrad teams at #iGEM22. We @unil @DMF_UNIL @FBM_UNIL @ecolebiolunil are very proud of you!!!🎉🥳🤩

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The Nobel Prize
The Nobel Prize@NobelPrize·
BREAKING NEWS: The Royal Swedish Academy of Sciences has decided to award the #NobelPrize in Chemistry 2018 with one half to Frances H. Arnold and the other half jointly to George P. Smith and Sir Gregory P. Winter.
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@ATJCagan @santosmoreno_j @ETasiudi @YSchaerli @unil @betulunlu86 @IgemUzh @EPFL_iGEM